Abstract

Individuals suffering from cancer, including hematological malignancies, are at increased risk of cardiovascular disease (CVD). Elevated levels of several biomarkers in blood are associated with an increased risk of CVD. The aim of this study was to investigate whether a subset of such CVD risk biomarkers was elevated in patients with untreated chronic lymphocytic leukemia (CLL). Blood plasma and serum from 139 CLL patients and 71 healthy age-matched controls were analyzed for 11 proposed CVD risk biomarkers. The CLL cohort displayed a more heterogeneous pattern of biomarker expression compared to controls. The majority, eight out of 11, analyzed CVD risk biomarkers differed significantly in concentrations between CLL patients and controls. Increased levels of the biomarkers GDF15 and myostatin have not previously been reported in CLL. Further prospective studies are warranted to investigate whether these biomarkers predict future cardiovascular events in patients with CLL.

摘要

患有癌症（包括血液系统恶性肿瘤）的个体患心血管疾病 (CVD) 的风险增加。血液中几种生物标志物水平升高与心血管疾病风险增加有关。本研究的目的是调查在未经治疗的慢性淋巴细胞白血病 (CLL) 患者中是否有一部分此类 CVD 风险生物标志物升高。分析了 139 名 CLL 患者和 71 名健康年龄匹配对照的血浆和血清中 11 种提出的 CVD 风险生物标志物。与对照相比，CLL 队列显示出更异质的生物标志物表达模式。大多数（11 个中有 8 个）分析的 CVD 风险生物标志物在 CLL 患者和对照组之间的浓度存在显着差异。以前在 CLL 中没有报道过生物标志物 GDF15 和肌肉生长抑制素水平升高。