Objectives: To evaluate the demographic and clinical characteristics of patients with Behçet’s syndrome (BS), and to define their associations with the presence of major organ involvement (MOI).

Method: Medical records of 2118 patients (964 males, 1154 females) were analysed retrospectively. MOI was defined as the presence of at least one of vascular, eye, nervous, or gastrointestinal system involvement. Univariable and multivariable binary and ordinal logistic regression analyses were applied to assess the factors that were potentially associated with MOI.

Results: The mean ± sd age at diagnosis was 30.5 ± 9.4 years. Genital ulcer and joint involvement were more common in females (both p < 0.001), while MOI was more frequent in males (p < 0.001). Genital ulcer (p < 0.001) and vascular involvement (p = 0.006) were more common in patients with a younger age at diagnosis, while joint involvement was more common in older patients. A total of 1097 patients (51.8%) had at least one MOI, 322 (15.2%) at least two MOIs, and 48 (2.3%) at least three MOIs. Male gender, smoking history, and absence of genital ulcer were significantly associated with MOI in multivariable binary logistic regression. Multivariable ordinal regression analyses confirmed the association between MOI and male gender and smoking, but not the protective effect of genital ulcers. In both regression analyses, we found no significant effects of age, human leucocyte antigen-B51, skin involvement, or joint involvement on MOI.

Conclusion: Male gender and positive smoking history have a significant influence on the presence of MOI in patients with BS.

目的：评估白塞综合征 (BS) 患者的人口统计学和临床​​特征，并确定其与主要器官受累 (MOI) 存在的关联。

方法：回顾性分析2118例患者（男964例，女1154例）的病历。MOI 被定义为存在血管、眼睛、神经或胃肠道系统中的至少一种。应用单变量和多变量二元和有序逻辑回归分析来评估可能与 MOI 相关的因素。

结果：诊断时的平均 ± sd 年龄为 30.5 ± 9.4 岁。生殖器溃疡和关节受累在女性中更为常见（均 p < 0.001），而 MOI 在男性中更为常见（p < 0.001）。生殖器溃疡 (p < 0.001) 和血管受累 (p = 0.006) 在诊断时年龄较小的患者中更常见，而关节受累在老年患者中更常见。共有 1097 名患者（51.8%）至少有一个 MOI，322 名（15.2%）至少有两个 MOI，48 名（2.3%）至少三个 MOI。在多变量二元逻辑回归中，男性、吸烟史和没有生殖器溃疡与 MOI 显着相关。多变量序数回归分析证实了 MOI 与男性和吸烟之间的关联，但没有证实生殖器溃疡的保护作用。在这两种回归分析中，

结论：男性和阳性吸烟史对 BS 患者 MOI 的存在有显着影响。