We compared cardiovascular magnetic resonance segmental native T1 against T2* values for the detection of myocardial iron overload (MIO) in thalassaemia major and we evaluated the clinical correlates of native T1 measurements. We considered 146 patients (87 females, 38.7 ± 11.1 years) consecutively enrolled in the Extension-Myocardial Iron Overload in Thalassaemia Network. T1 and T2* values were obtained in the 16 left ventricular (LV) segments. LV function parameters were quantified by cine images. Post-contrast late gadolinium enhancement (LGE) and T1 images were acquired. 64.1% of segments had normal T2* and T1 values while 10.1% had pathologic T2* and T1 values. In 526 (23.0%) segments, there was a pathologic T1 and a normal T2* value while 65 (2.8%) segments had a pathologic T2* value but a normal T1 and an extracellular volume (ECV) ≥ 25% was detected in 16 of 19 segments where ECV was quantified. Global native T1 was independent from gender or LV function but decreased with increasing age. Patients with replacement myocardial fibrosis had significantly lower native global T1. Patients with cardiac complications had significantly lower native global T1. The combined use of both segmental native T1 and T2* values could improve the sensitivity for detecting MIO. Native T1 is associated with cardiac complications in thalassaemia major.

中文翻译：

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通过心血管磁共振原生节段性 T1 映射测得的心肌铁过载：一种与心脏并发症相关的敏感方法

我们将心血管磁共振节段性天然 T1 与 T2* 值进行比较，以检测重型地中海贫血的心肌铁过载 (MIO)，并评估了天然 T1 测量值的临床相关性。我们考虑了 146 名患者（87 名女性，38.7 ± 11.1 岁）连续参加了地中海贫血网络中的扩展-心肌铁过载网络。在 16 个左心室 (LV) 节段中获得了 T1 和 T2* 值。LV 功能参数通过电影图像量化。获得了增强后钆增强 (LGE) 和 T1 图像。64.1% 的节段具有正常的 T2* 和 T1 值，而 10.1% 的节段具有病理性 T2* 和 T1 值。在 526 (23.0%) 个节段中，有病理性 T1 和正常 T2* 值，而 65 (2. 8%) 节段具有病理性 T2* 值，但在对 ECV 进行量化的 19 个节段中的 16 个节段中检测到正常 T1 和细胞外体积 (ECV) ≥ 25%。全球本地 T1 独立于性别或 LV 功能，但随着年龄的增长而下降。患有替代性心肌纤维化的患者具有显着较低的天然整体 T1。有心脏并发症的患者具有显着较低的天然整体 T1。节段性原生 T1 和 T2* 值的结合使用可以提高检测 MIO 的灵敏度。天然 T1 与重型地中海贫血的心脏并发症有关。有心脏并发症的患者具有显着较低的天然整体 T1。节段性原生 T1 和 T2* 值的结合使用可以提高检测 MIO 的灵敏度。天然 T1 与重型地中海贫血的心脏并发症有关。有心脏并发症的患者具有显着较低的天然整体 T1。节段性原生 T1 和 T2* 值的结合使用可以提高检测 MIO 的灵敏度。天然 T1 与重型地中海贫血的心脏并发症有关。