Introduction: False memory, observed as intrusion errors or false positives (FPs), is prevalent in patients with Alzheimer’s disease, but has yet to be thoroughly investigated in patients with amnestic mild cognitive impairment (a-MCI) with Alzheimer’s disease pathology (ADP). We analyzed false versus veridical memory in individuals with a-MCI and measured the utility of false memory for ADP discrimination. Methods: Patients with a-MCI who received neuropsychological testing and amyloid PET were included. Patients were categorized into “with” and “without ADP” groups according to PET results. Memory tests assessed veridical and false memory, and the verity of patient responses was analyzed. A logistic regression model was used to evaluate false memory efficiency in discriminating ADP, and the sensitivity and specificity at the optimal level were estimated using the receiver-operating characteristic curve. Results: Thirty-seven ADP and 46 non-ADP patients were enrolled. The ADP group made more FPs in the recognition tests, and their response verity was significantly lower in every delayed memory test. No group difference, however, was observed in the veridical memory. The logistic regression analysis demonstrated that as the FPs increased, the risk of ADP increased 1.31 and 1.36 times in the verbal and visual recognition tests, respectively. The discriminatory accuracy of the FPs was estimated “low” to “moderate” in the visual and verbal recognition, respectively, with an optimal cutoff above 2.5. Conclusion: Increased false memory was the only feature to discriminate ADP from non-ADP in individuals with a-MCI. Further studies regarding false memory and its mechanism are warranted.
Dement Geriatr Cogn Disord Extra 2021;11:172–180

中文翻译：

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遗忘性轻度认知障碍患者的错误记忆和阿尔茨海默病病理学：淀粉样蛋白 PET 研究

简介：错误记忆，被观察为侵入错误或假阳性 (FPs)，在阿尔茨海默病患者中很普遍，但在患有阿尔茨海默病病理学 (ADP) 的遗忘型轻度认知障碍 (a-MCI) 患者中尚待彻底调查. 我们分析了 a-MCI 个体的错误记忆与真实记忆，并测量了错误记忆对 ADP 辨别的效用。方法：包括接受神经心理学测试和淀粉样蛋白 PET 的 a-MCI 患者。根据 PET 结果将患者分为“有”和“无 ADP”组。记忆测试评估了真实和错误的记忆，并分析了患者反应的真实性。使用逻辑回归模型评估辨别ADP的错误记忆效率，并使用接收器操作特征曲线估计最佳水平的敏感性和特异性。结果：招募了 37 名 ADP 患者和 46 名非 ADP 患者。ADP组在识别测试中做出更多的FP，并且他们在每次延迟记忆测试中的反应真实性显着降低。然而，在真实记忆中没有观察到组间差异。逻辑回归分析表明，随着 FPs 的增加，ADP 的风险在语言和视觉识别测试中分别增加了 1.31 和 1.36 倍。在视觉和语言识别中，FP 的判别准确度分别被估计为“低”到“中等”，最佳截止值高于 2.5。结论：增加的错误记忆是区分 a-MCI 个体中 ADP 与非 ADP 的唯一特征。关于错误记忆及其机制的进一步研究是必要的。
Dement Geriatr Cogn Disord Extra 2021;11:172–180