Dynamic DNA-based biomaterials have seen rapid growth with great potential for healthcare and biomedicine. They are notably benefited by programmability, biocompatibility, chemical synthesis/modification, and enzymatic manipulation of nucleic acids. In this review, the molecular basis and resources of DNA-based biomaterials are first summarized. Next, the current state of the art of the construction principles of stimuli-responsive DNA-based biomaterials are classified, predominantly highlighting the timely dynamic DNA-based biomaterials that interact with external, macroscopic, and molecular stimuli. Finally, the challenges are discussed and an outlook on this promising class of dynamic DNA-based interactive materials is given. Further development of such dynamic biomaterials with programmable and orchestrated functions for intelligent biomedicine is predicted.

基于动态 DNA 的生物材料发展迅速，在医疗保健和生物医学领域具有巨大潜力。它们特别受益于核酸的可编程性、生物相容性、化学合成/修饰和酶促操作。在这篇综述中，首先总结了基于 DNA 的生物材料的分子基础和资源。接下来，对刺激响应性基于 DNA 的生物材料的构建原理的当前技术水平进行了分类，主要突出了与外部、宏观和分子刺激相互作用的及时动态的基于 DNA 的生物材料。最后，讨论了挑战，并给出了对这类有前途的基于 DNA 的动态交互式材料的展望。