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Chemistry of Oxadiazole Analogues: Current Status and Applications
Russian Journal of Bioorganic Chemistry ( IF 1 ) Pub Date : 2021-06-11 , DOI: 10.1134/s1068162021030092
Anjali Jha , Anik Sen , Rama Rao Malla

Abstract

Oxadiazoles are heterocyclic compounds in numerous approved, and experimental drugs, bioactive molecules, liquid crystals, diodes and in solar cell applications. It is one of the primary molecules studied in recent times and is a vital molecule employed in medicinal-chemistry for the preparation of anticancer, anti-HIV, anti-TB, anti-hepatitis etc. Research in the chemistry of the oxadiazole derivatives has been developed with the evolution of each application area and the need for target molecules with specific properties. A large number of in vivo applications for the oxadiazole analogues have also been performed. Presently, it has also been introduced as both auxiliary acceptor and spacer in dye-sensitized solar cell study with significant efficiency. Extensive literature has been documented the different applications of this versatile scaffold. The current review described some critical synthetic approaches to form such a vital moiety along with its derivatives and discussed its diverse applications, which includes the moiety in pharmacological activities, diode, liquid crystal, and solar cell fields. The review also describes some advancement in the field from our group, and also, the scope of the further study has been introduced.



中文翻译:

恶二唑类似物的化学:现状和应用

摘要

恶二唑是许多已批准的实验药物、生物活性分子、液晶、二极管和太阳能电池应用中的杂环化合物。它是近年来研究的主要分子之一,是药物化学中用于制备抗癌、抗 HIV、抗结核、抗肝炎等的重要分子。 恶二唑衍生物的化学研究已随着每个应用领域的发展和对具有特定特性的目标分子的需求而开发。还进行了大量恶二唑类似物的体内应用。目前,它也被引入作为染料敏化太阳能电池研究中的辅助受体和间隔物,并具有显着的效率。大量文献记载了这种多功能支架的不同应用。目前的综述描述了形成这种重要部分及其衍生物的一些关键合成方法,并讨论了其多种应用,包括药理活性、二极管、液晶和太阳能电池领域中的部分。该综述还描述了我们小组在该领域的一些进展,并介绍了进一步研究的范围。

更新日期:2021-06-11
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