Abstract—

By the reaction of thiophen-2-carbaldehyde with rhodanine derivatives, 5-thiophen-2-ylmethylene-2-thioxothiazolidin-4-ones have been synthesized. The resulting (4-oxo-5-thiophen-2-ylmethylen-2-thioxothiazolidin-3-yl)alkane carboxylic acids have been used to acylate the biogenic amine tryptamine and its derivatives. As a result, a number of novel N-[2-(5-[R-1H-indol-3-yl)-ethyl]-2-(4-oxo-5-thiophen-2-ylmethylen-2-thioxothiazolidin-3-yl)carbamides have been synthesized. The antimicrobial and antitumor properties of the resulting compounds have been tested. Compounds with a high antimicrobial activity against Staphylococcus aureus and Cryptococcus neoformans have been identified.

中文翻译：

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5-Thiophen-2-ylmethylen-2-Thioxothiazolidin-4-one 衍生物的合成、抗菌和抗肿瘤特性

摘要-

通过噻吩-2-甲醛与罗丹宁衍生物的反应，合成了5-噻吩-2-基亚甲基-2-硫代噻唑烷-4-酮。所得的 (4-oxo-5-thiophen-2-ylmethylen-2-thioxothiazolidin-3-yl) 烷烃羧酸已用于酰化生物胺色胺及其衍生物。因此，许多新的N -[2-(5-[ R -1 H -indol-3-yl)-ethyl]-2-(4-oxo-5-thiophen-2-ylmethylen-2-thioxothiazolidin -3-基）脲已被合成。已测试所得化合物的抗微生物和抗肿瘤特性。已鉴定出对金黄色葡萄球菌和新型隐球菌具有高抗菌活性的化合物。