Abstract

As a new type of multifunctional material, metal−organic frameworks (MOFs) have a wide application prospect in the field of chiral separation. In this study, a homochiral MOF [Ni(S-mal)(bpy)]_n was synthesized by the reaction of S-malic acid (S-mal) and 4,4′-bipyridine (bpy) with nickel acetate. The homochiral MOF [Ni(S-mal)(bpy)]_n was explored as a new chiral stationary phase for HPLC separation of racemic compounds using n-hexane−isopropanol as a mobile phase. A series of racemic compounds were separated on this column. The results showed that the homochiral MOF column exhibited good chiral recognition ability toward six racemic compounds including amlodipine, ibuprofen, flurbiprofen, propranolol hydrochloride, chlorphenamine maleate and 1-p-chlorobenzyl−ethanol. The homochiral MOF column also offered good reproducibility and stability for the enantioseparation.

中文翻译：

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同手性金属-有机骨架 [Ni(S-mal)(bpy)]n 用于通过高效液相色谱法分离外消旋化合物

摘要

金属有机骨架（MOFs）作为一种新型多功能材料，在手性分离领域有着广阔的应用前景。在这项研究中，通过 S-苹果酸 ( S-mal ) 和 4,4'-联吡啶 ( bpy ) 与乙酸镍反应合成了同手性 MOF [Ni(S-mal)(bpy)] _n。同手性 MOF [Ni(S-mal)(bpy)] _n被探索作为一种新的手性固定相，用于外消旋化合物的 HPLC 分离，使用n-己烷-异丙醇作为流动相。在该柱上分离了一系列外消旋化合物。结果表明，同手性MOF柱对氨氯地平、布洛芬、氟比洛芬、盐酸普萘洛尔、马来酸氯苯那敏和1-对氯苄基乙醇等六种外消旋化合物表现出良好的手性识别能力。同手性 MOF 色谱柱也为对映分离提供了良好的重现性和稳定性。