ABSTRACT

Mitochondrial noncoding RNAs (mt-ncRNAs) include noncoding RNAs inside the mitochondria that are transcribed from the mitochondrial genome or nuclear genome, and noncoding RNAs transcribed from the mitochondrial genome that are transported to the cytosol or nucleus. Recent findings have revealed that mt-ncRNAs play important roles in not only mitochondrial functions, but also other cellular activities. This review proposes a classification of mt-ncRNAs and outlines the emerging understanding of mitochondrial circular RNAs (mt-circRNAs), mitochondrial microRNAs (mitomiRs), and mitochondrial long noncoding RNAs (mt-lncRNAs), with an emphasis on their identification and functions.

摘要

线粒体非编码 RNA (mt-ncRNA) 包括线粒体内从线粒体基因组或核基因组转录的非编码 RNA，以及从线粒体基因组转录并转运到细胞质或细胞核的非编码 RNA。最近的研究结果表明，mt-ncRNAs 不仅在线粒体功能中发挥重要作用，而且在其他细胞活动中也发挥着重要作用。这篇综述提出了 mt-ncRNA 的分类，并概述了对线粒体环状 RNA (mt-circRNA)、线粒体 microRNA (mitomiRs) 和线粒体长非编码 RNA (mt-lncRNA) 的新认识，重点是它们的识别和功能。