Members of the Cryptococcus gattii species complex are notorious causes of cryptococcosis as they often cause severe, life-threatening infections. Here we describe a case of a severe disseminated C. deuterogattii infection in a previously healthy patient who was initially treated with amphotericin B, 5-fluorocytosine and fluconazole, which led to a good neurological response, but the infection in the lungs remained unaltered and was not completely resolved until switching the antifungal therapy to isavuconazole. The infection was likely acquired during a one-month stay at the Azores Islands, Portugal. Environmental sampling did not yield any cryptococcal isolate; therefore, the source of this apparent autochthonous case could not be determined. Molecular typing showed that the cultured C. deuterogattii isolates were closely related to the Vancouver Island outbreak-genotype.

该成员隐球菌gattii种复杂的是隐球菌病的原因臭名昭著，因为他们往往会导致严重的，危及生命的感染。在这里，我们描述了一个严重播散的C. deuterogattii一名既往健康患者感染，最初接受两性霉素 B、5-氟胞嘧啶和氟康唑治疗，神经系统反应良好，但肺部感染未改变，直到将抗真菌治疗改为艾沙康唑后才完全缓解。感染很可能是在葡萄牙亚速尔群岛逗留一个月期间获得的。环境采样未产生任何隐球菌分离株；因此，无法确定这一明显的本土案例的来源。分子分型表明，培养的C. deuterogattii分离株与温哥华岛暴发基因型密切相关。