Patients with alcohol dependence and depressive disorder are known to report a higher number of adverse childhood experiences (ACEs) and show differences in reproductive history compared to the general population. Males and females differ in both prevalence of ACEs and their way of coping with them. The present study tested the indirect effects of ACEs (measured by graded and cumulative effects, i.e., ≥ 4 vs. ˂ 4 of 13 ACE categories and by childhood physical and sexual abuse alone) on reproductive history (age at first intercourse, lifetime number of sex partners, age at first pregnancy, planning the first pregnancy, lifetime number of pregnancies, lifetime number of children, ever getting married, age at first marriage) mediated by alcohol dependence, depressive disorder, and lack of psychiatric history in 126 adult females. Six significant mediation models were found for the indirect effect of ACEs (graded and cumulative effect and childhood physical abuse alone) on age at first intercourse via alcohol dependence and lack of psychiatric history. Path analyses showed that alcohol dependence was a partial mediator and lack of psychiatric history was a complete mediator between ACEs’ graded and cumulative effects on age at first intercourse. The mediating effects of alcohol dependence and lack of psychiatric history were complete for direct effects between physical abuse and age at first intercourse. This study is the first to document the indirect role of ACEs on age at first intercourse via alcohol dependence and lack of psychiatric history in adult females.

众所周知，酒精依赖和抑郁症患者报告的不良童年经历 (ACE) 数量更多，并且与一般人群相比，生殖史也存在差异。男性和女性在 ACE 的患病率和应对方式方面存在差异。本研究测试了 ACE（通过分级和累积效应衡量，即 13 个 ACE 类别中≥ 4 对 ˂ 4 以及仅通过儿童期身体虐待和性虐待）对生殖史（第一次性交的年龄、终生的性伴侣、首次怀孕的年龄、首次怀孕的计划、终生怀孕次数、终生子女数、是否结婚、初婚年龄）由酒精依赖、抑郁症和 126 名成年女性缺乏精神病史介导。发现了六个重要的中介模型，用于通过酒精依赖和缺乏精神病史对首次性交年龄的 ACE（分级和累积效应和仅儿童身体虐待）的间接影响。路径分析表明，酒精依赖是部分中介因素，缺乏精神病史是 ACE 对首次性交年龄的分级和累积影响之间的完全中介因素。酒精依赖和缺乏精神病史的中介作用对于身体虐待和第一次性交年龄之间的直接影响是完整的。这项研究首次记录了 ACE 通过酒精依赖和成年女性缺乏精神病史对首次性交年龄的间接作用。