当前位置: X-MOL 学术J. Adv. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Neurophysiological mechanisms of cancer-induced bone pain
Journal of Advanced Research ( IF 10.7 ) Pub Date : 2021-06-11 , DOI: 10.1016/j.jare.2021.06.006
Xuan-Qi Zheng 1, 2 , Yu-Hao Wu 2 , Jin-Feng Huang 1, 2 , Ai-Min Wu 1, 2
Affiliation  

Background

Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditions and the complexity of neuropathic pain, related mechanisms have been continuously supplemented but have not been perfected.

Aim of Review

Therefore, the current review highlights the latest progress in basic research on the field and proposes potential therapeutic targets, representative drugs and upcoming therapies.

Key Scientific Concepts of Review

Notably, factors such as central sensitization, neuroinflammation, glial cell activation and an acidic environment are considered to be related to neuropathic pain in CIBP. Nonetheless, further research is needed to ascertain the mechanism of CIBP in order to develop highly effective drugs. Moreover, more attention needs to be paid to the care of patients with advanced cancer.



中文翻译:

癌症引起的骨痛的神经生理机制

背景

癌症引起的骨痛(CIBP)是影响癌症幸存者生活质量的重要因素。此外,目前的临床实践和科学研究表明,神经性疼痛是CIBP的代表性组成部分。然而,鉴于癌症病情的多变性和神经病理性疼痛的复杂性,相关机制不断补充但尚未完善。

审查目的

因此,本综述重点介绍了该领域基础研究的最新进展,并提出了潜在的治疗靶点、代表性药物和即将推出的疗法。

审查的关键科学概念

值得注意的是,中枢敏化、神经炎症、胶质细胞活化和酸性环境等因素被认为与 CIBP 的神经病理性疼痛有关。尽管如此,仍需要进一步研究来确定 CIBP 的机制,以开发高效的药物。此外,对于晚期癌症患者的护理也需要更加重视。

更新日期:2021-06-11
down
wechat
bug