After antibiotic treatment, a subpopulation of bacteria often remains and can lead to recalcitrant infections. This subpopulation, referred to as persisters, evades antibiotic treatment through numerous mechanisms such as decreased uptake of small molecules and slowed growth. Membrane perturbing small molecules have been shown to eradicate persisters as well as render these populations susceptible to antibiotic treatment. Chemotype similarities have emerged suggesting amphiphilic heteroaromatic compounds possess ideal properties to increase membrane fluidity and such molecules warrant further investigation as effective agents or potentiators against persister cells.

中文翻译：

---

使用膜扰动小分子来靶向慢性持续性感染

抗生素治疗后，细菌亚群通常会残留下来，并可能导致顽固性感染。这种亚群被称为持续者，通过多种机制逃避抗生素治疗，例如减少小分子的摄取和减缓生长。膜扰动小分子已被证明可以根除持久存在并使这些群体对抗生素治疗敏感。化学型相似性的出现表明两亲性杂芳族化合物具有增加膜流动性的理想特性，并且此类分子值得进一步研究作为针对持续细胞的有效药剂或增效剂。