A Systematic Review of the Costs Relating to Non-pharmaceutical Interventions Against Infectious Disease Outbreaks,Applied Health Economics and Health Policy

当前位置： X-MOL 学术 › Appl. Health Econ. Health Policy › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A Systematic Review of the Costs Relating to Non-pharmaceutical Interventions Against Infectious Disease Outbreaks
Applied Health Economics and Health Policy ( IF 3.6 ) Pub Date : 2021-06-11 , DOI: 10.1007/s40258-021-00659-z
Janetta E Skarp ₁ , Laura E Downey _{1,

2} , Julius W E Ohrnberger ₁ , Lucia Cilloni ₁ , Alexandra B Hogan ₁ , Abagael L Sykes ₁ , Susannah S Wang ₁ , Hiral Anil Shah ₁ , Mimi Xiao ₁ , Katharina Hauck ₁

Affiliation

Background

Non-pharmaceutical interventions (NPIs) are the cornerstone of infectious disease outbreak response in the absence of effective pharmaceutical interventions. Outbreak strategies often involve combinations of NPIs that may change according to disease prevalence and population response. Little is known with regard to how costly each NPI is to implement. This information is essential to inform policy decisions for outbreak response.

Objective

To address this gap in existing literature, we conducted a systematic review on outbreak costings and simulation studies related to a number of NPI strategies, including isolating infected individuals, contact tracing and quarantine, and school closures.

Methods

Our search covered the MEDLINE and EMBASE databases, studies published between 1990 and 24 March 2020 were included. We included studies containing cost data for our NPIs of interest in pandemic, epidemic, and outbreak response scenarios.

Results

We identified 61 relevant studies. There was substantial heterogeneity in the cost components recorded for NPIs in outbreak costing studies. The direct costs of NPIs for which costing studies existed also ranged widely: isolating infected individuals per case: US$141.18 to US$1042.68 (2020 values), tracing and quarantine of contacts per contact: US$40.73 to US$93.59, social distancing: US$33.76 to US$167.92, personal protection and hygiene: US$0.15 to US$895.60.

Conclusion

While there are gaps and heterogeneity in available cost data, the findings of this review and the collated cost database serve as an important resource for evidence-based decision-making for estimating costs pertaining to NPI implementation in future outbreak response policies.

中文翻译：

对与传染病暴发的非药物干预相关成本的系统评价

背景

在缺乏有效药物干预的情况下，非药物干预 (NPI) 是传染病暴发应对的基石。爆发策略通常涉及可能根据疾病流行率和人口反应而变化的 NPI 组合。关于每个 NPI 的实施成本如何，我们知之甚少。这些信息对于为应对疫情做出决策提供信息至关重要。

客观的

为了解决现有文献中的这一差距，我们对与许多 NPI 策略相关的爆发成本计算和模拟研究进行了系统评价，包括隔离感染者、接触者追踪和隔离以及学校关闭。

方法

我们的搜索涵盖了 MEDLINE 和 EMBASE 数据库，包括 1990 年至 2020 年 3 月 24 日之间发表的研究。我们纳入的研究包含我们感兴趣的 NPI 在大流行、流行病和疫情应对情景中的成本数据。

结果

我们确定了 61 项相关研究。在疫情成本计算研究中记录的 NPI 成本构成存在很大的异质性。存在成本核算研究的 NPI 的直接成本也有很大差异：每个病例隔离感染者：141.18 美元至 1042.68 美元（2020 年值），每个接触者的追踪和隔离接触者：40.73 美元至 93.59 美元，社交距离：33.76 美元至167.92 美元，个人防护和卫生：0.15 美元至 895.60 美元。