Osteons are cylindrical structures of bone created by matrix resorbing osteoclasts, followed by osteoblasts that deposit new bone. Osteons align with the principal loading direction and it is thought that the osteoclasts are directed by osteocytes, the mechanosensitive cells that reside inside the bone matrix. These osteocytes are presumably controlled by interstitial fluid flow, induced by the physiological loading of bones. Here I consider the stimulation of osteocytes while the osteon is closed by osteoblasts. In a conceptual finite element model, bone is considered a poro-elastic material and subjected to locomotion-induced loading conditions. It appears that the magnitude of flow is constant along the closing cone, while shear strain rate in the bone matrix diminishes linearly with the deposition of bone. This suggests that shear strain rate, rather than fluid flow, is the physical cue that controls osteocytes and bone deposition in newly formed osteons.

中文翻译：

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闭合骨：骨细胞感知应变率而不是流体流动吗？

骨是由基质吸收破骨细胞，然后是沉积新骨的成骨细胞产生的圆柱形骨结构。骨与主要加载方向对齐，据认为破骨细胞是由骨细胞引导的，骨细胞是位于骨基质内的机械敏感细胞。这些骨细胞可能是由骨骼的生理负荷诱导的间质液流动控制的。在这里，我考虑了在骨细胞被成骨细胞封闭时对骨细胞的刺激。在概念性有限元模型中，骨骼被视为多孔弹性材料并承受运动引起的载荷条件。沿着闭合锥体的流动幅度似乎是恒定的，而骨基质中的剪切应变率随着骨的沉积而线性减小。这表明剪切应变率，