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The role of fecal sulfur metabolome in inflammatory bowel diseases
International Journal of Medical Microbiology ( IF 4.1 ) Pub Date : 2021-06-10 , DOI: 10.1016/j.ijmm.2021.151513
Alesia Walker 1 , Philippe Schmitt-Kopplin 2
Affiliation  

Sulfur metabolism and sulfur-containing metabolites play an important role in the human digestive system, and sulfur compounds and pathways are associated with inflammatory bowel diseases (IBD). In fact, cysteine metabolism results in the production of taurine and sulfate, and gut microbes catabolize them into hydrogen sulfide, a signaling molecule with various biological functions. Besides metabolites originating from sulfur metabolism, several other sulfur-containing metabolites of different classes were detected in human feces, consisting of non-volatile and volatile compounds. Sulfated steroids and bile acids such as taurine-conjugated bile acids are the major classes along with sulfur amino acids and sulfur-containing peptides. Indeed, sulfur-containing metabolites were described in stool samples from healthy subjects, patients suffering from colorectal cancer or IBD. In metabolomics-driven studies, around 50 known sulfur-containing metabolites were linked to IBD. Taurine, taurocholic acid, taurochenodeoxycholic acid, methionine, methanethiol and hydrogen sulfide were regularly reported in IBD studies, and most of them were elevated in stool samples from IBD patients. We summarized from this review that there is strong interplay between perturbed gut microbiota in IBD, and the consistently higher abundance of sulfur-containing metabolites, which potentially represent substrates for sulfidogenic bacteria such as Bilophila or Escherichia and promote their growth. These bacteria might shift their metabolism towards the degradation of taurine and cysteine and therefore to a higher hydrogen sulfide production.



中文翻译:

粪便硫代谢组在炎症性肠病中的作用

硫代谢和含硫代谢物在人体消化系统中起着重要作用,硫化合物和途径与炎症性肠病 (IBD) 相关。事实上,半胱氨酸代谢导致牛磺酸和硫酸盐的产生,肠道微生物将它们分解代谢为硫化氢,硫化氢是一种具有多种生物学功能的信号分子。除了源自硫代谢的代谢物外,还在人类粪便中检测到了其他几种不同类别的含硫代谢物,由非挥发性和挥发性化合物组成。硫酸化的类固醇和胆汁酸,如牛磺酸结合的胆汁酸,与硫氨基酸和含硫肽一起是主要类别。事实上,在健康受试者的粪便样本中描述了含硫代谢物,患有结肠直肠癌或 IBD 的患者。在代谢组学驱动的研究中,大约 50 种已知的含硫代谢物与 IBD 相关。IBD 研究中经常报告牛磺酸、牛磺胆酸、牛磺鹅脱氧胆酸、蛋氨酸、甲硫醇和硫化氢,其中大部分在 IBD 患者的粪便样本中升高。我们从这篇综述中总结说,IBD 中肠道微生物群紊乱与持续较高丰度的含硫代谢物之间存在强烈的相互作用,这些代谢物可能代表硫化菌的底物,例如 甲硫醇和硫化氢在 IBD 研究中经常报告,其中大部分在 IBD 患者的粪便样本中升高。我们从这篇综述中总结说,IBD 中肠道菌群紊乱与持续较高丰度的含硫代谢物之间存在强烈的相互作用,这些代谢物可能代表硫化菌的底物,例如 甲硫醇和硫化氢在 IBD 研究中经常报告,其中大部分在 IBD 患者的粪便样本中升高。我们从这篇综述中总结说,IBD 中肠道微生物群紊乱与持续较高丰度的含硫代谢物之间存在强烈的相互作用,这些代谢物可能代表硫化菌的底物,例如BilophilaEscherichia并促进它们的生长。这些细菌可能会将它们的代谢转向牛磺酸和半胱氨酸的降解,从而产生更高的硫化氢。

更新日期:2021-06-18
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