Antibodies are an essential element of the immune response to infection, and in long-term protection upon re-exposure to the same micro-organism. Antibodies are produced by plasmablasts and plasma cells, the terminally differentiated cells of the B lymphocyte lineage. These relatively rare populations, collectively termed antibody secreting cells (ASCs), have developed highly specialized transcriptional and metabolic pathways to facilitate their extraordinarily high rates of antibody synthesis and secretion. In this review, we discuss the gene regulatory network that controls ASC identity and function, with a particular focus on the processes that influence the transcription, translation, folding, modification and secretion of antibodies. We will address how ASCs have adapted their transcriptional, metabolic and protein homeostasis pathways to sustain such high rates of antibody production, and the roles that the major ASC regulators, the transcription factors, Irf4, Blimp-1 and Xbp1, play in co-ordinating these processes.

中文翻译：

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控制浆细胞功能的基因调控网络

抗体是对感染的免疫反应的基本要素，并且在再次接触同一微生物时具有长期保护作用。抗体由浆母细胞和浆细胞产生，浆细胞是 B 淋巴细胞谱系的终末分化细胞。这些相对稀有的群体，统称为抗体分泌细胞 (ASC)，它们已经发展出高度特化的转录和代谢途径，以促进其异常高的抗体合成和分泌速率。在这篇综述中，我们讨论了控制 ASC 身份和功能的基因调控网络，特别关注影响抗体转录、翻译、折叠、修饰和分泌的过程。我们将讨论 ASC 如何适应它们的转录，