Studies on environmental-friendly surfactants are essential to potentially replace those highly toxic and non-biodegradable commercially available surfactants. Two biocompatible polymeric anionic (AS1) and nonionic (NS1) surfactants were successfully synthesised from palm oil derivatives via polyesterification. The cytotoxicity of surfactants was measured by in vitro succinate dehydrogenase activity (MTT assay). Results revealed that both surfactants achieved cell viability above 80% against human keratinocytes (HaCaT), mouse fibroblasts (3T3), mouse hepatocytes (H2.35) and canine kidney cells (MDCK) in both dose- and time-dependent manners. Antimicrobial potential of both surfactants was evaluated using minimum bactericidal concentration (MBC) assay. Results indicated that AS1 had a significant antimicrobial activity against most of the tested Gram-positive bacteria. Meanwhile, only one of the Gram-negative bacteria (Acinetobacter baumannii) was successfully reduced by NS1. Both surfactants were subsequently compounded into natural rubber latex (NRL). From rheological study, AS1 exhibited better viscosity behaviour with longer linear viscoelastic region (LVR) towards high ammonia (HA) NRL, signifying its potential in providing stability in the latex environment.

对环境友好型表面活性剂的研究对于潜在替代那些剧毒且不可生物降解的市售表面活性剂至关重要。通过聚酯化，从棕榈油衍生物中成功合成了两种生物相容性聚合物阴离子 (AS1) 和非离子 (NS1) 表面活性剂。通过体外琥珀酸脱氢酶活性（MTT测定）测量表面活性剂的细胞毒性。结果表明，两种表面活性剂均以剂量和时间依赖性方式对人角质形成细胞 (HaCaT)、小鼠成纤维细胞 (3T3)、小鼠肝细胞 (H2.35) 和犬肾细胞 (MDCK) 的细胞活力达到 80% 以上。使用最小杀菌浓度 (MBC) 测定法评估两种表面活性剂的抗菌潜力。结果表明，AS1 对大多数测试的革兰氏阳性菌具有显着的抗菌活性。同时，只有一种革兰氏阴性菌（NS1 成功地减少了鲍曼不动杆菌 (Acinetobacter baumannii )。随后将两种表面活性剂混合到天然橡胶胶乳 (NRL) 中。从流变学研究来看，AS1 表现出更好的粘度行为，具有更长的线性粘弹性区域 (LVR)，朝向高氨 (HA) NRL，表明其在乳胶环境中提供稳定性的潜力。