Mounting evidence has demonstrated that a myriad of developmental signaling pathways, such as the Wnt, Notch, Hedgehog and Hippo, are frequently deregulated and play a critical role in regulating cancer stem cell (CSC) activity in human cancers, including gynecologic malignancies. In this review article, we describe an overview of various signaling pathways in human cancers. We further discuss the developmental roles how these pathways regulate CSCs from experimental evidences in gynecologic cancers. Moreover, we mention several compounds targeting CSCs in gynecologic cancers to enhance the treatment outcomes. Therefore, these signaling pathways might be the potential targets for developing targeted therapy in gynecologic cancers.

越来越多的证据表明，无数的发育信号通路，如 Wnt、Notch、Hedgehog 和 Hippo，经常被解除管制，并在调节人类癌症（包括妇科恶性肿瘤）中的癌症干细胞 (CSC) 活性中发挥关键作用。在这篇评论文章中，我们概述了人类癌症中各种信号通路。我们进一步讨论了这些途径如何从妇科癌症的实验证据中调节 CSC 的发育作用。此外，我们提到了几种针对妇科癌症中 CSC 的化合物，以提高治疗效果。因此，这些信号通路可能是开发妇科癌症靶向治疗的潜在靶点。