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Distinct modulation of tracheal and laryngopharyngeal cough via superior laryngeal nerve in cat
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-06-10 , DOI: 10.1016/j.resp.2021.103716
Michal Simera 1 , Marcel Veternik 1 , Lukas Martvon 1 , Zuzana Kotmanova 1 , Soheil Mostafavi 1 , Ondrej Bosko 1 , Olga Kralikova 1 , Ivan Poliacek 1
Affiliation  

Unilateral and bilateral cooling and bilateral transsection of the superior laryngeal nerve (SLN) were employed to modulate mechanically induced tracheobronchial (TB) and laryngopharyngeal (LPh) cough in 12 anesthetized cats. There was little effect of SLN block or cut on TB. Bilateral SLN cooling reduced the number of LPh (<50 %, p < 0.05), amplitudes of diaphragm EMG activity (<55 %, p < 0.05), and cough expiratory efforts (<40 %, p < 0.01) during LPh. Effects after unilateral SLN cooling were less pronounced. Temporal analysis of LPh showed only shortening of diaphragm and abdominal muscles burst overlap in the inspiratory–expiratory transition after unilateral SLN cooling. Bilateral cooling reduced both expiratory phase and total cough cycle duration. There was no significant difference in the average effects of cooling left or right SLN on LPh or TB as well as no differences in contralateral and ipsilateral diaphragm and abdominal EMG amplitudes.

Our results show that reduced afferent drive in the SLN markedly attenuates LPh with virtually no effect on TB.



中文翻译:

猫通过喉上神经对气管和咽喉咳嗽的不同调节

单侧和双侧冷却和双侧喉上神经 (SLN) 的横断用于调节 12 只麻醉猫的机械性气管支气管 (TB) 和喉咽 (LPh) 咳嗽。SLN阻断或切断对结核病影响不大。双侧 SLN 冷却降低了 LPh 的数量(<50 %,p < 0.05)、膈肌 EMG 活动的幅度(<55 %,p < 0.05)和 LPh 期间的咳嗽呼气努力(<40 %,p < 0.01)。单侧 SLN 冷却后的效果不太明显。LPh 的时间分析显示,在单侧 SLN 冷却后,吸气 - 呼气过渡中膈肌和腹部肌肉爆发重叠仅缩短。双侧冷却减少了呼气阶段和总咳嗽周期持续时间。

我们的结果表明,SLN 中传入驱动的减少显着减弱了 LPh,而对 TB 几乎没有影响。

更新日期:2021-06-15
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