Observing the dynamic progress of the brain in response to peripheral nerve stimulation as a whole is the basis for a deeper understanding of overall brain function; however, it remains a great challenge. In this work, a novel mini-invasive orthogonal recording method is developed to observe the overall evoked cortex potential (ECP) in rat brain. A typical ECP atlas with recognizable waveforms in the rat cortex corresponding to the median, ulnar, and radial nerve trunks and subdivided branches is acquired. Reproducible exciting temporal–spatial progress in the rat brain is obtained and visualized for the first time. Changes in the ECPs and exciting sequences in the cortex four months after median nerve transection are also observed. The results suggest that the brain’s response to peripheral stimulation has precise and reproducible temporal–spatial properties. This resource can serve as a testbed to explore the overall functional interaction and dynamic remodeling mechanisms between the peripheral and central nervous systems over time.

观察大脑整体响应周围神经刺激的动态进展，是深入了解整体大脑功能的基础；然而，这仍然是一个巨大的挑战。在这项工作中，开发了一种新的微创正交记录方法来观察大鼠大脑中的整体诱发皮层电位 (ECP)。获得了一个典型的 ECP 图谱，在大鼠皮层中具有可识别的波形，对应于正中、尺骨和桡神经干和细分分支。首次获得并可视化了大鼠大脑中可重复的令人兴奋的时空进展。还观察到正中神经横断后四个月皮质中 ECP 和兴奋序列的变化。结果表明，大脑对外围刺激的反应具有精确且可重复的时空特性。该资源可以作为试验平台，探索外周和中枢神经系统之间的整体功能相互作用和动态重塑机制。