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Gastric Hyperplastic Polyps Can Shrink After Discontinuation of Proton Pump Inhibitors: A Case Series Compared With Continuation of Proton Pump Inhibitors
Journal of Clinical Gastroenterology ( IF 2.9 ) Pub Date : 2022-03-01 , DOI: 10.1097/mcg.0000000000001577
Mitsuhiro Nikaido 1 , Shin'ichi Miyamoto 1, 2 , Takahiro Utsumi 1 , Takahiro Shimizu 1 , Yuki Nakanishi 1 , Ken Kumagai 1 , Mari Teramura 1 , Takeshi Setoyama 1, 3 , Hiroshi Seno 1
Affiliation  

Goal: 

This study investigated whether gastric hyperplastic polyps (GHPs) shrink after discontinuation of proton pump inhibitor (PPI) alone.

Background: 

Long-term use of PPIs has been reported to increase the incidence of GHPs, which sometimes bleed and cause anemia. We experienced a patient whose recurrent hemorrhagic GHPs associated with long-term use of PPIs had disappeared after discontinuation of PPIs.

Study: 

This study was conducted retrospectively at Kyoto University Hospital. Patients with histologically confirmed GHPs who had been taking PPIs for >6 months and who had undergone a repeat endoscopy within 2 years were included. Polyp shrinkage was defined as the disappearance of polyps or a reduction of >50% in the long diameter of the largest polyp.

Results: 

Six patients who discontinued PPIs were compared with 17 patients who continued PPIs. Polyp shrinkage was significantly more frequent in the PPI-discontinuation group (5/6, 83%) than in the PPI continuation group (0/17, 0%) (P<0.001). In 2 patients in the PPI-discontinuation group, the polyps completely disappeared finally.

Conclusion: 

These findings suggest that discontinuation of PPIs can shrink GHPs in patients using PPIs.



中文翻译:

停止使用质子泵抑制剂后胃增生性息肉会缩小:一系列病例与继续使用质子泵抑制剂进行比较

目标: 

本研究调查了单独使用质子泵抑制剂(PPI)后胃增生性息肉(GHP)是否会缩小。

背景: 

据报道,长期使用 PPI 会增加 GHP 的发生率,有时会导致出血并导致贫血。我们遇到过一位患者,其与长期使用 PPI 相关的复发性出血性 GHP 在停止 PPI 后消失了。

学习: 

这项研究是在京都大学医院回顾性进行的。经组织学证实患有 GHP、服用 PPI 超过 6 个月且在 2 年内接受过重复内窥镜检查的患者也被纳入其中。息肉收缩定义为息肉消失或最大息肉长径减少>50%。

结果: 

将 6 名停止 PPI 的患者与 17 名继续 PPI 的患者进行了比较。PPI 停止组 (5/6, 83%) 息肉缩小的发生率明显高于 PPI 继续组 (0/17, 0%) ( P <0.001)。停药组中有2名患者息肉最终完全消失。

结论: 

这些发现表明,停止使用 PPI 可以减少使用 PPI 的患者的 GHP。

更新日期:2022-02-21
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