The exact role of adipokines in the pathogenesis of gestational diabetes mellitus (GDM) still remains not fully clear, and multiple studies have analyzed their potential contribution to the pathophysiology of this pregnancy complication. This study is aimed at evaluating serum chemerin, lipocalin 2, and apelin concentrations in GDM and healthy pregnant patients, assessing the correlation between these adipokines, and suggesting the potential role of these cytokines in the diagnosis and pathophysiology of GDM. The study comprised 237 pregnant women: 153 with GDM and 84 with physiological pregnancy. Serum concentrations of chemerin, lipocalin 2, and apelin were obtained at 24–29 weeks of gestation. The mean concentrations of chemerin and lipocalin 2 were significantly higher in the GDM group. The concentration of apelin was slightly higher in the GDM group, but not statistically significant. The strong positive correlation between chemerin and lipocalin 2 concentrations was noticed in both groups. Our data suggest that maternal chemerin and lipocalin 2 may play a significant role in the pathophysiology of GDM. We imply that these adipokines could potentially be established as novel biomarkers for the early identification of GDM. However, more studies are needed to analyze the effect of these adipokines on glucose metabolism during early pregnancy.

中文翻译：

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Chemerin、Lipocalin 2 和 Apelin 在妊娠期糖尿病诊断和病理生理学中的潜在作用

脂肪因子在妊娠期糖尿病 (GDM) 发病机制中的确切作用仍不完全清楚，多项研究分析了它们对这种妊娠并发症的病理生理学的潜在贡献。本研究旨在评估 GDM 和健康孕妇患者的血清 chemerin、lipocalin 2 和 apelin 浓度，评估这些脂肪因子之间的相关性，并提示这些细胞因子在 GDM 诊断和病理生理学中的潜在作用。该研究包括 237 名孕妇：153 名 GDM 和 84 名生理妊娠。在妊娠 24-29 周时获得凯莫瑞、脂质运载蛋白 2 和 apelin 的血清浓度。GDM 组的凯莫瑞和脂质运载蛋白 2 的平均浓度显着升高。GDM组apelin浓度略高，但无统计学意义。在两组中都发现了凯莫瑞和脂质运载蛋白 2 浓度之间的强正相关。我们的数据表明，母体凯莫瑞和脂质运载蛋白 2 可能在 GDM 的病理生理学中起重要作用。我们暗示这些脂肪因子可能被确立为早期识别 GDM 的新型生物标志物。然而，需要更多的研究来分析这些脂肪因子对妊娠早期葡萄糖代谢的影响。我们暗示这些脂肪因子可能被确立为早期识别 GDM 的新型生物标志物。然而，需要更多的研究来分析这些脂肪因子对妊娠早期葡萄糖代谢的影响。我们暗示这些脂肪因子可能被确立为早期识别 GDM 的新型生物标志物。然而，需要更多的研究来分析这些脂肪因子对妊娠早期葡萄糖代谢的影响。