ABSTRACT

Red djulis (Chenopodium formosanum) is a native grain plant, and shows that it has anti-oxidant and anti-inflammatory effects. However, it was still unclear whether unhulled red djulis extracts promoted collagen production and anti-aging. This study aimed to explore whether the unhulled red djulis extracts had anti-aging properties. Using unhulled red djulis extracts to treat human fibroblasts for functional analysis, and used HPLC to analyze the effective components of red djulis. This study found that unhulled red djulis extracts can increase the repairing ability of the skin cells, and increased skin-barrier-related genes, antioxidant-related genes expression. In addition, it increased collagen-related genes, and inhibited AGEs and melanin formation. Finally, we isolated six active ingredients from the unshelled Red Julie extract, which can increase collagen. Thus, the unhulled red djulis extracts can affect gene expressions related to the skin barrier, antioxidation, and collagen.

摘要

Red djulis ( Chenopodium formosanum) 是一种原生谷物植物，表明它具有抗氧化和抗炎作用。然而，尚不清楚未脱壳的红木提取物是否促进胶原蛋白的产生和抗衰老。本研究旨在探讨未脱壳的红木提取物是否具有抗衰老特性。用未脱壳的红木提取物处理人成纤维细胞进行功能分析，采用高效液相色谱法分析红木的有效成分。本研究发现，未脱壳的红枣提取物可以提高皮肤细胞的修复能力，并增加皮肤屏障相关基因、抗氧化相关基因的表达。此外，它还增加了与胶原蛋白相关的基因，并抑制了 AGEs 和黑色素的形成。最后，我们从带壳的红朱莉提取物中分离出六种可以增加胶原蛋白的活性成分。因此，