Experiments were performed in 110 ISA Brown egg production hens (Gallus gallus), kept from 15 to 26 weeks of age in enriched (furnished) housing technology. The present objective was to investigate the presence of single nucleotide polymorphisms (SNPs) of the ATP2B1 gene and their effects on calcium homeostasis in laying hens. The plasma membrane calcium-transporting ATPase 1 gene (ATP2B1) in hens is located on chromosome 1, region 43 273 706 – 43 305 815 bp. The ATP2B1 gene has 21 exons, and in this study three were genotyped. In each experimental group of animals, only alleles without deletions in exon 10 and only allele A in exon 12 were found. In exon 8, only genotypes CC/CC, TT/CC and TT/TT were found. These genotypes are associated with femur breaking strength, bone diameter, bone marrow diameter and compact bone thickness. No significant effects of SNPs in exon 8 on bone characteristics were found.

中文翻译：

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ATP2B1基因单核苷酸多态性与蛋鸡骨参数的相关性

实验是在 110 只 ISA 褐蛋母鸡 (Gallus gallus) 中进行的，这些母鸡从 15 至 26 周龄饲养在富集（配备）的鸡舍技术中。目前的目的是研究 ATP2B1 基因单核苷酸多态性 (SNP) 的存在及其对蛋鸡钙稳态的影响。母鸡的质膜钙转运 ATPase 1 基因 (ATP2B1) 位于 1 号染色体的 43 273 706 – 43 305 815 bp 区域。ATP2B1 基因有 21 个外显子，在本研究中对 3 个进行了基因分型。在每个实验动物组中，仅发现外显子10中没有缺失的等位基因和外显子12中仅发现等位基因A。在外显子 8 中，仅发现基因型 CC/CC、TT/CC 和 TT/TT。这些基因型与股骨断裂强度、骨直径、骨髓直径和致密骨厚度相关。