Hydrotalcites (HTs) are the potential substitute to conventional base catalysts. HTs are useful in efficient syntheses of various heterocycles, such as chromenes, pyrans, pyrazoles, triazoles, using multi-component reactions. This review focuses on the chemistry of HTs and particularly hydrotalcites and related materials in the synthesis of heterocycles. The effects of preparation method and, physico-chemical parameters, such as calcination, molar ratio of metals, role of intercalated ions, surface area, on the catalytic activities are discussed. Along with technical aspects, this review also unlocks various untouched areas in developing sustainable catalyst for syntheses of heterocycles, drugs, etc. for the future.

水滑石 (HT) 是传统碱催化剂的潜在替代品。HT 可用于使用多组分反应有效合成各种杂环，例如色烯、吡喃、吡唑、三唑。本综述重点关注 HT 的化学，特别是水滑石和杂环合成中的相关材料。讨论了制备方法和物理化学参数，如煅烧、金属摩尔比、嵌入离子的作用、表面积对催化活性的影响。除了技术方面，本综述还揭示了未来在开发用于合成杂环化合物、药物等的可持续催化剂方面的各种未触及领域。