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Menstrual Phase Does Not Influence Ventilatory Responses to Group III/IV Afferent Signaling in Eumenorrheic Young Females
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-06-09 , DOI: 10.1016/j.resp.2021.103712
Emma Lee 1 , Kathryn Vera 2 , Ninitha Asirvatham-Jeyaraj 3 , Daniel Chantigian 1 , Mia Larson 4 , Manda Keller-Ross 5
Affiliation  

Estrogen can reduce sympathetic activity, but its effects on minute ventilation (VE) with group III/IV afferent activation remain unclear. This study examined the influence of estrogen on VE during lower-extremity exercise with group III/IV activation. Females completed two identical visits in follicular and ovulatory menstrual phases. Nine participants (age 25 ± 4 years) performed three minutes of baseline steady-state cycle ergometry and then group III/IV afferents were further activated with proximal thigh cuffs inflated to 20, 60, and 100 mmHg (randomized) for two minutes and five minutes of cycling between each occlusion. Metaboreflex was isolated by post-exercise circulatory occlusion. Ventilation was measured continuously and rating of perceived exertion (RPE) was recorded for each stage. During rest and exercise, VE (p < 0.001) and tidal volume (VT) (p = 0.033) were higher in the follicular than ovulatory phase. Minute ventilation, VT, and respiratory rate (RR) with ergoreflex and metaboreflex activation were similar across phases. With cuff occlusion of 100 mmHg, VE increased from baseline by 26.3 ± 7.0 L/min in the follicular phase (p < 0.001) and by 25.3±7.7 L/min in the ovulatory phase (p < 0.001), with no difference between phases (p > 0.05); RR and VT increased similarly with occlusion, also with no phase differences. In eumenorrheic females, menstrual phase influences ventilation but not ventilatory responses to group III/IV isolation.



中文翻译:

月经期不影响月经期年轻女性对 III/IV 组传入信号的通气反应

雌激素可降低交感神经活动,但其对III/IV 组传入激活的分钟通气量 (V E ) 的影响仍不清楚。本研究探讨了雌激素对 V E的影响在 III/IV 组激活的下肢运动中。女性在卵泡期和排卵期完成了两次相同的访视。9 名参与者(年龄 25 ± 4 岁)进行了 3 分钟的基线稳态循环测功,然后将 III/IV 组传入进一步激活,将近端大腿袖带充气至 20、60 和 100 mmHg(随机),持续 2 分钟和 5 分钟每个闭塞之间的循环分钟数。通过运动后循环闭塞分离代谢反射。连续测量通气并记录每个阶段的感知用力 (RPE) 等级。在休息和运动期间,V E ( p  < 0.001) 和潮气量 (V T ) ( p = 0.033)在卵泡期高于排卵期。具有麦角反射和代谢反射激活的分钟通气量、V T和呼吸频率 (R R ) 在各个阶段相似。袖带闭塞 100 mmHg 时,V E在卵泡期从基线增加 26.3 ± 7.0 L/min(p  < 0.001)和在排卵期增加 25.3±7.7 L/min(p  < 0.001),两者之间没有差异阶段 ( p  > 0.05); R R和 V T随着闭塞的增加类似地增加,也没有相位差。在月经不调的女性中,月经期影响通气,但不影响对 III/IV 组隔离的通气反应。

更新日期:2021-06-09
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