A versatile and environmentally friendly method for the synthesis of various organophosphorus compounds have been developed under microware conditions. We have synthesized a series of the trifluoromethyl phosphonates via Phospha-Brook rearrangement between dialkylphosphite and 3-(trifluoroacetyl)coumarins using KF/Al₂O₃ as a highly efficient solid catalyst under solventless conditions. Catalyst reuse, ease of separation of the pure product, and high yields are some of the unique features of this process. In addition, the mycelial growth rate method was used to examine the in vitro antifungal activities of the phosphates 4a-o against Phytophthora capsici, Fusarium oxysporum vasinfectum, Bipolaris maydis and Alternaria solani at 500 µg/mL. The results showed that compound 4n exhibited significant anti-Phytophthora capsici activity with inhibitory index of 86%.

已开发出一种在微量条件下合成各种有机磷化合物的通用且环保的方法。我们在无溶剂条件下使用 KF/Al ₂ O ₃作为高效固体催化剂，通过亚磷酸二烷基酯和 3-（三氟乙酰基）香豆素之间的 Phospha-Brook 重排合成了一系列三氟甲基膦酸酯。催化剂重复使用、易于分离纯产品和高产率是该工艺的一些独特之处。此外，采用菌丝体生长速率法检测了磷酸盐4a-o对辣椒疫霉、尖孢镰刀菌、Bipolaris maydis和Alternaria solani，浓度为 500 µg/mL。结果表明，化合物4n具有显着的抗辣椒疫霉活性，抑制指数为86%。