Objective. This study aimed to investigate the effect of bilateral transcranial direct current stimulation (tDCS) on the electroencephalography (EEG) amplitude and coherence in male patients with opioid use disorder (OUD), who were under methadone therapy. It compares the effects of active versus sham tDCS. Methods. This is a double-blind sham-controlled clinical trial. Participants were 30 male patients with OUD; they were divided into 3 groups of left anode/right cathode tDCS, right anode/left cathode tDCS, and sham tDCS. Their brainwave activity was measured by quantitative EEG before study and then active groups underwent tDCS (2 mA, 20 min) applied over their right/left dorsolateral prefrontal cortex (DLPFC) for 10 consecutive days. After stimulation, they were re-assessed. The collected data were analyzed in SPSS, MATLAB, and NeuroGuide v.2 applications. Results. After active tDCS, a significant decrease in amplitude of slow brain waves (delta, theta, and alpha) in prefrontal, frontal, occipital, and parietal areas, and an increase in the coherence of beta, delta, and theta frequency bands in the parietal, central, and temporal regions of addicts were reported. In the sham group, there was a significant decrease in the amplitude of the alpha wave and in the coherence of delta and theta waves. Conclusion. The active tDCS over the right/left DLPFC, as a noninvasive and complementary treatment, can modulate the amplitude and coherence of brainwaves in patients with OUD.

客观。本研究旨在探讨双侧经颅直流电刺激 (tDCS) 对接受美沙酮治疗的男性阿片类药物使用障碍 (OUD) 患者脑电图 (EEG) 幅度和连贯性的影响。它比较了主动与假 tDCS 的效果。方法. 这是一项双盲假对照临床试验。参与者是 30 名 OUD 男性患者；分为左阳极/右阴极tDCS、右阳极/左阴极tDCS和假tDCS 3组。在研究前通过定量 EEG 测量他们的脑电波活动，然后活动组在其右/左背外侧前额叶皮层 (DLPFC) 上连续 10 天接受 tDCS（2 mA，20 分钟）。刺激后，他们被重新评估。收集的数据在 SPSS、MATLAB 和 NeuroGuide v.2 应用程序中进行分析。结果. 活动 tDCS 后，前额叶、额叶、枕叶和顶叶区域的慢脑波（δ、θ 和 α）幅度显着降低，顶叶 β、δ 和 θ 频带的相干性增加、中枢和颞叶区域都有成瘾者的报告。在假手术组中，α波的幅度以及δ波和θ波的相干性显着降低。结论。右/左 DLPFC 上的主动 tDCS 作为一种无创和补充治疗，可以调节 OUD 患者脑电波的幅度和相干性。