The aim of this study was to assess the relationship of cluster of differentiation 117 (CD117) expression with the clinicopathological characteristics and the prognosis in patients with non-small cell lung cancer (NSCLC). No meta-analysis concerning the correlation of CD117 expression with clinical and prognostic values of the patients with NSCLC is reported. A systematic literature search was conducted to achieve eligible studies. The combined odds ratios (ORs) or hazard ratios (HRs: multivariate Cox analysis) with their 95% confidence intervals (CIs) were calculated in this analysis. Final 17 eligible studies with 4,893 NSCLC patients using immunohistochemical detection were included in this meta-analysis. CD117 expression was not correlated with gender (male vs. female), clinical stage (stages 3–4 vs. stages 1–2), tumor grade (grade 3 vs. grades 1–2), T-stage (T-stages 3–4 vs. T-stages 0–2), distal metastasis, and disease-free survival (DFS) of NSCLC (all p values #x3e;0.05). CD117 expression was associated with lymph node metastasis (positive vs. negative: OR = 0.74, 95% CI = 0.56–0.97, p = 0.03), histological type (adenocarcinoma (AC) versus squamous cell carcinoma (SCC): OR = 1.74, 95% CI = 1.26–2.39, p = 0.001), and a worse overall survival (OS) (HR = 1.89, 95% CI = 1.22–2.92, p = 0.004). The expression of CD117 was significantly higher in AC than in SCC. CD117 may be an independent prognostic indicator for worse OS in NSCLC.
Pathobiology

中文翻译：

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CD117 在非小细胞肺癌中的临床和预后意义：系统荟萃分析

本研究的目的是评估非小细胞肺癌（NSCLC）患者分化簇117（CD117）表达与临床病理特征和预后的关系。目前尚未报道CD117表达与NSCLC患者临床和预后价值相关性的荟萃分析。进行了系统的文献检索以获得合格的研究。在此分析中计算了组合优势比 (OR) 或风险比（HR：多变量 Cox 分析）及其 95% 置信区间 (CI)。本荟萃分析纳入了最终 17 项符合条件的研究，涉及 4,893 名 NSCLC 患者，使用免疫组织化学检测。CD117 表达与性别（男性与女性）、临床分期（3-4 期与 1-2 期）、肿瘤分级（3 级与 1-2 级）、T 分期（T 分期 3）不相关。 –4 与 T 分期 0–2)、远端转移和 NSCLC 的无病生存 (DFS)（所有p值#x3e；0.05）。CD117 表达与淋巴结转移（阳性与阴性：OR = 0.74，95% CI = 0.56-0.97，p = 0.03）、组织学类型（腺癌（AC）与鳞状细胞癌（SCC）：OR = 1.74， 95% CI = 1.26–2.39，p = 0.001），总生存期 (OS) 较差（HR = 1.89，95% CI = 1.22–2.92，p = 0.004）。AC 中 CD117 的表达显着高于 SCC。CD117 可能是 NSCLC 中 OS 较差的独立预后指标。
病理生物学