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Early life stress is associated with earlier emergence of permanent molars
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.412 ) Pub Date : 2021-06-15 , DOI: 10.1073/pnas.2105304118
Cassidy L. McDermott, Katherine Hilton, Anne T. Park, Ursula A. Tooley, Austin L. Boroshok, Muralidhar Mupparapu, JoAnna M. Scott, Erin E. Bumann, Allyson P. Mackey

Exposure to adversity can accelerate biological aging. However, existing biomarkers of early aging are either costly and difficult to collect, like epigenetic signatures, or cannot be detected until late childhood, like pubertal onset. We evaluated the hypothesis that early adversity is associated with earlier molar eruption, an easily assessed measure that has been used to track the length of childhood across primates. In a preregistered analysis (n = 117, ages 4 to 7 y), we demonstrate that lower family income and exposure to adverse childhood experiences (ACEs) are significantly associated with earlier eruption of the first permanent molars, as rated in T2-weighted magnetic resonance images (MRI). We replicate relationships between income and molar eruption in a population-representative dataset (National Health and Nutrition Examination Survey; n = 1,973). These findings suggest that the impact of stress on the pace of biological development is evident in early childhood, and detectable in the timing of molar eruption.



中文翻译:

早期生活压力与恒磨牙的早期出现有关

暴露在逆境中会加速生物老化。然而,现有的早期衰老生物标志物要么成本高昂且难以收集(如表观遗传特征),要么直到儿童晚期(如青春期开始)才能被检测到。我们评估了早期逆境与早期磨牙萌出相关的假设,这是一种易于评估的衡量标准,已被用于追踪灵长类动物的童年长度。在预注册分析中 ( n= 117,年龄 4 至 7 岁),我们证明较低的家庭收入和暴露于不良童年经历 (ACE) 与第一恒磨牙的早期萌出显着相关,如 T2 加权磁共振图像 (MRI) 所述。我们在具有代表性的数据集(国家健康和营养检查调查;n = 1,973)中复制了收入和磨牙之间的关系。这些发现表明,压力对生物发育速度的影响在儿童早期就很明显,并且可以在磨牙萌出的时间中检测到。

更新日期:2021-06-09
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