Ferroptosis plays an important role in traumatic brain injury (TBI). The p53 protein is a major mediator of ferroptosis. However, the role of p53-mediated ferroptosis in TBI has not been studied. Sirtuin 2 (SIRT2) exerts a protective effects role in TBI, although the underlying mechanism of this protection remains unclear. In the present study, we tested the hypothesis that that SIRT2 mitigates TBI by regulating p53-mediated ferroptosis.

中文翻译：

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在实验性创伤性脑损伤后，SIRT2 抑制加剧了 p53 介导的小鼠铁死亡。

铁死亡在创伤性脑损伤（TBI）中起重要作用。p53 蛋白是铁死亡的主要介质。然而，尚未研究 p53 介导的铁死亡在 TBI 中的作用。Sirtuin 2 (SIRT2) 在 TBI 中发挥保护作用，尽管这种保护的潜在机制仍不清楚。在本研究中，我们检验了 SIRT2 通过调节 p53 介导的铁死亡来减轻 TBI 的假设。