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Representational drift in primary olfactory cortex
Nature ( IF 42.778 ) Pub Date : 2021-06-09 , DOI: 10.1038/s41586-021-03628-7
Carl E. Schoonover, Sarah N. Ohashi, Richard Axel, Andrew J. P. Fink

Perceptual constancy requires the brain to maintain a stable representation of sensory input. In the olfactory system, activity in primary olfactory cortex (piriform cortex) is thought to determine odour identity1,2,3,4,5. Here we present the results of electrophysiological recordings of single units maintained over weeks to examine the stability of odour-evoked responses in mouse piriform cortex. Although activity in piriform cortex could be used to discriminate between odorants at any moment in time, odour-evoked responses drifted over periods of days to weeks. The performance of a linear classifier trained on the first recording day approached chance levels after 32 days. Fear conditioning did not stabilize odour-evoked responses. Daily exposure to the same odorant slowed the rate of drift, but when exposure was halted the rate increased again. This demonstration of continuous drift poses the question of the role of piriform cortex in odour perception. This instability might reflect the unstructured connectivity of piriform cortex6,7,8,9,10,11,12, and may be a property of other unstructured cortices.



中文翻译:

初级嗅觉皮层的代表性漂移

知觉恒常性要求大脑保持对感官输入的稳定表征。在嗅觉系统中,初级嗅觉皮层(梨状皮层)的活动被认为决定气味特征1,2,3,4,5. 在这里,我们展示了保持数周的单个单位的电生理记录结果,以检查小鼠梨状皮层中气味诱发反应的稳定性。尽管梨状皮层的活动可用于随时区分气味剂,但气味引起的反应会在数天到数周内漂移。在第一个记录日训练的线性分类器的性能在 32 天后接近机会水平。恐惧条件反射并不能稳定气味诱发的反应。每天接触相同的气味会减慢漂移的速度,但是当停止接触时,速度再次增加。这种持续漂移的演示提出了梨状皮层在气味感知中的作用的问题。这种不稳定性可能反映了梨状皮层的非结构化连接6,7,8,9,10,11,12,并且可能是其他非结构化皮质的属性。

更新日期:2021-06-09
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