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Carbon dot-based materials for wound healing applications
Advances in Natural Sciences: Nanoscience and Nanotechnology Pub Date : 2021-06-04 , DOI: 10.1088/2043-6262/abffc9
Hamide Ehtesabi , Reyhaneh Nasri

Skin repair is a complicated procedure in the human body. A proper clinical outcome cannot usually be provided by the present treatments to heal wounds. Reduction of infection, moisturisation of the wound, stimulation of the healing mechanisms, acceleration of the wound closure, and reduction of scar formation require more curative procedure. Nanomaterials are used in managing wound healing by representing an exclusive instrument with a specific design for close reflection of the physiologic procedures in injured tissues. Carbon dots (CDs) are tiny fluorescent carbon nanoparticles with a size range below 10 nm in diameter. Throughout the last few years, these nanomaterials have gained a rising ground because of their less toxicity, adjustable fluorescence, and physicochemical specifications. The wound healing field has witnessed a novel perspective owing to CDs-based therapies. This review summarises the state-of-the-art CDs-based wound healing applications and highlights their advantages over conventional wound healing methods. Following an introduction, the first section covers synthesise methods of CDs for wound healing application. Then, methods of wound treatment by using CDs were classified. After that, models to study the effect of CDs on wound healing have been studied. A final section covers the role of using CDs in wound healing. The conclusion summarises the current status and gives an outlook on potential future trends.



中文翻译:

用于伤口愈合应用的碳点基材料

皮肤修复是人体中一个复杂的过程。目前的治疗通常不能提供适当的临床结果来治愈伤口。减少感染、滋润伤口、刺激愈合机制、加速伤口闭合和减少疤痕形成需要更多的治疗程序。纳米材料通过代表具有特定设计的专用仪器来管理伤口愈合,用于密切反映受伤组织的生理过程。碳点 (CD) 是直径小于 10 nm 的微小荧光碳纳米粒子。在过去的几年中,这些纳米材料因其毒性较小、荧光可调和物理化学规格而获得了越来越多的关注。由于基于 CD 的疗法,伤口愈合领域出现了新的前景。本综述总结了最先进的基于 CD 的伤口愈合应用,并强调了它们相对于传统伤口愈合方法的优势。在介绍之后,第一部分涵盖了用于伤口愈合应用的 CD 的合成方法。然后,对使用 CD 治疗伤口的方法进行了分类。之后,研究了 CD 对伤口愈合影响的模型。最后一部分介绍了使用 CD 在伤口愈合中的作用。结论总结了目前的状况,并对未来的潜在趋势进行了展望。在介绍之后,第一部分涵盖了用于伤口愈合应用的 CD 的合成方法。然后,对使用CDs进行伤口处理的方法进行了分类。之后,研究了 CD 对伤口愈合影响的模型。最后一部分介绍了使用 CD 在伤口愈合中的作用。结论总结了目前的状况,并对未来的潜在趋势进行了展望。在介绍之后,第一部分涵盖了用于伤口愈合应用的 CD 的合成方法。然后,对使用CDs进行伤口处理的方法进行了分类。之后,研究了 CD 对伤口愈合影响的模型。最后一部分介绍了使用 CD 在伤口愈合中的作用。结论总结了目前的状况,并对未来的潜在趋势进行了展望。

更新日期:2021-06-04
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