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Does participant’s age impact on tDCS induced fields?Insights from computational simulations
Biomedical Physics & Engineering Express Pub Date : 2021-06-07 , DOI: 10.1088/2057-1976/ac0547
Hannah McCann 1, 2 , Leandro Beltrachini 1, 2
Affiliation  

Objective: Understanding the induced current flow from transcranial direct current stimulation (tDCS) is essential for determining the optimal dose and treatment. Head tissue conductivities play a key role in the resulting electromagnetic fields. However, there exists a complicated relationship between skull conductivity and participant age, that remains unclear. We explored how variations in skull electrical conductivities, particularly as a suggested function of age, affected tDCS induced electric fields. Approach: Simulations were employed to compare tDCS outcomes for different intensities across head atlases of varying age. Three databases were chosen to demonstrate differing variability in skull conductivity with age and how this may affect induced fields. Differences in tDCS electric fields due to proposed age-dependent skull conductivity variation, as well as deviations in grey matter, white matter and scalp, were compared and the most influential tissues determined. Main results: tDCS induced peak electric fields significantly negatively correlated with age, exacerbated by employing proposed age-appropriate skull conductivity (according to all three datasets). Uncertainty in skull conductivity was the most sensitive to changes in peak fields with increasing age. These results were revealed to be directly due to changing skull conductivity, rather than head geometry alone. There was no correlation between tDCS focality and age. Significance: Accurate and individualised head anatomy and in vivo skull conductivity measurements are essential for modelling tDCS induced fields. In particular, age should be taken into account when considering stimulation dose to precisely predict outcomes.



中文翻译:

参与者的年龄是否会影响 tDCS 感应场?计算模拟的见解

目的:了解经颅直流电刺激 (tDCS) 产生的感应电流对于确定最佳剂量和治疗至关重要。头部组织电导率在产生的电磁场中起着关键作用。然而,颅骨电导率与参与者年龄之间存在复杂的关系,目前尚不清楚。我们探讨了颅骨电导率的变化,特别是作为建议的年龄函数,如何影响 tDCS 感应电场。方法:模拟用于比较不同年龄头部图谱中不同强度的 tDCS 结果。选择了三个数据库来展示颅骨电导率随年龄的不同变化以及这可能如何影响感应场。比较了由于提出的与年龄相关的颅骨电导率变化以及灰质、白质和头皮的偏差而导致的 tDCS 电场差异,并确定了最有影响的组织。主要结果: tDCS 诱导的峰值电场与年龄显着负相关,采用建议的适合年龄的颅骨电导率(根据所有三个数据集)加剧了这种情况。随着年龄的增长,颅骨电导率的不确定性对峰值场的变化最为敏感。这些结果被揭示直接归因于颅骨电导率的变化,而不仅仅是头部几何形状。tDCS 焦点和年龄之间没有相关性。意义:准确和个性化的头部解剖和体内颅骨电导率测量对于模拟 tDCS 感应场至关重要。特别是,在考虑刺激剂量以准确预测结果时,应考虑年龄。

更新日期:2021-06-07
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