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Microdosimetry modeling with Auger emitters in generalized cell geometry
Physics in Medicine & Biology ( IF 3.5 ) Pub Date : 2021-06-03 , DOI: 10.1088/1361-6560/ac01f5
Teresa L Palmer 1 , Kinga Tkacz-Stachowska 1 , Roar Skartlien 1 , Nasrin Omar 1 , Sindre Hassfjell 1 , Andreas Mjøs 1 , Johannes Bergvoll 1 , Ellen M Brevik 1 , Olaug Hjelstuen 1
Affiliation  

A microdosimetry model was developed for the prediction of cell viability for irregular non-spherical cells that were irradiated by low energy, short range Auger electrons. Measured cell survival rates for LNCaP prostate cancer were compared to the computational results for the radioisotopes 177Lu and 161Tb (conjugated to PSMA). The cell geometries used for the computations were derived directly from the cell culture images. A general computational approach was developed to handle arbitrary cell geometries, based on distance probability distribution functions (PDFs) derived from basic image processing. The radiation calculations were done per coarse grained PDF bin to reduce computation time, rather than on a pixel/voxel basis. The radiation dose point kernels over the full electron spectrum were derived using Monte Carlo simulations for energies below 50 eV to account for the propagation of Auger electrons over length scales at and below a cellular radius. The relative importance of short range Auger electrons were evaluated between the two nuclide types. The microdosimetry results were consistent with the cell viability measurements, and it was found that 161Tb was more efficient than 177Lu primarily due to the short range Auger electrons. We foresee that imaging based microdosimetry can be used to evaluate the relative therapeutic effect between various nuclide candidates.



中文翻译:

在广义细胞几何中使用俄歇发射器进行微剂量学建模

开发了一种微剂量学模型,用于预测被低能量、短程俄歇电子照射的不规则非球形细胞的细胞活力。将测量的 LNCaP 前列腺癌的细胞存活率与放射性同位素177 Lu 和161的计算结果进行比较Tb(与 PSMA 结合)。用于计算的细胞几何形状直接来自细胞培养图像。基于源自基本图像处理的距离概率分布函数 (PDF),开发了一种通用计算方法来处理任意细胞几何形状。辐射计算是按粗粒度 PDF bin 进行的,以减少计算时间,而不是基于像素/体素。使用 Monte Carlo 模拟对低于 50 eV 的能量进行了全电子光谱上的辐射剂量点内核,以解释俄歇电子在细胞半径处和以下的长度尺度上的传播。在两种核素类型之间评估了短程俄歇电子的相对重要性。微剂量测定结果与细胞活力测量结果一致,161 Tb 比177 Lu 更有效,主要是由于短程俄歇电子。我们预见基于成像的微剂量学可用于评估各种候选核素之间的相对治疗效果。

更新日期:2021-06-03
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