Background. SARS-CoV-2 has spread worldwide with different dynamics in each region. We aimed to describe the clinical characteristics and to explore risk factors of death, critical care admission, and use of invasive mechanical ventilation in hospitalized patients with SARS-CoV-2 pneumonia in a high-altitude population living in Bogotá, Colombia. Methods. We conducted a concurrent cohort study of adult patients with laboratory-confirmed SARS-CoV-2 pneumonia. Demographic, clinical, and treatment data were extracted from electronic records. Univariate and multivariable methods were performed to investigate the relationship between each variable and outcomes at 28 days of follow-up. Results. 377 adults (56.8% male) were included in the study, of whom 85 (22.6%) died. Nonsurvivors were older on average than survivors (mean age, 56.7 years [SD 15.8] vs. 70.1 years [SD 13.9]; ) and more likely male (28 [32.9%] vs. 57 [67.1%]; ). Most patients had at least one underlying disease (333 [88.3%]), including arterial hypertension (149 [39.5%]), overweight (145 [38.5%]), obesity (114 [30.2%]), and diabetes mellitus (82 [21.8%]). Frequency of critical care admission (158 [41.9%]) and invasive mechanical ventilation (123 [32.6%]) was high. Age over 65 years (OR 9.26, 95% CI 3.29–26.01; ), ICU admission (OR 12.37, 95% CI 6.08–25.18; ), and arterial pH higher than 7.47 (OR 0.25, 95% CI 0.08–0.74; ) were independently associated with in-hospital mortality. Conclusions. In this study of in-hospital patients with SARS-CoV-2 pneumonia living at high altitude, frequency of death was similar to what has been reported. ICU admission and use of invasive mechanical ventilation were high. Risk factors as older age, ICU admission, and arterial pH were associated with mortality.

中文翻译：

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成人高海拔地区SARS-CoV-2肺炎患者的特征及临床病程

背景。SARS-CoV-2 已在全球范围内以不同的动态传播。我们旨在描述居住在哥伦比亚波哥大的高海拔人群的 SARS-CoV-2 肺炎住院患者的临床特征并探讨死亡、重症监护入院和使用有创机械通气的危险因素。方法。我们对实验室确诊的 SARS-CoV-2 肺炎成年患者进行了一项同步队列研究。从电子记录中提取人口统计学、临床和治疗数据。使用单变量和多变量方法来研究每个变量与 28 天随访结果之间的关系。结果. 377 名成年人（56.8% 男性）被纳入研究，其中 85 人（22.6%）死亡。非幸存者的平均年龄大于幸存者（平均年龄，56.7 岁 [SD 15.8] vs. 70.1 岁 [SD 13.9]；），更有可能是男性（28 [32.9%] vs. 57 [67.1%]；）。大多数患者至少有一种潜在疾病 (333 [88.3%])，包括动脉高血压 (149 [39.5%])、超重 (145 [38.5%])、肥胖 (114 [30.2%]) 和糖尿病 (82 [21.8%]）。重症监护（158 [41.9%]）和有创机械通气（123 [32.6%]）的频率很高。65 岁以上（OR 9.26，95% CI 3.29–26.01；), ICU 入住 (OR 12.37, 95% CI 6.08–25.18;)，并且动脉 pH 值高于 7.47（OR 0.25，95% CI 0.08–0.74；)与院内死亡率独立相关。结论。在这项针对生活在高海拔地区的 SARS-CoV-2 肺炎住院患者的研究中，死亡频率与报道的相似。ICU 入住率和有创机械通气的使用率很高。年龄较大、入住 ICU 和动脉 pH 值等危险因素与死亡率相关。