We evaluated whether the association between deviant peer affiliation and onset of substance use is conditional upon sex and sympathetic nervous system (SNS) reactivity as measured by pre-ejection period (PEP). Community-sampled adolescents (N = 251; M = 15.78 years; 53% female; 66% White, 34% Black) participated in three waves. PEP reactivity was collected during a mirror star-tracer stress task. Alcohol, marijuana, tobacco, or any substance use, as well as binge drinking and sexual activity involving substance use were outcomes predicted by affiliation with deviant peers and two- and three-way interactions with sex and PEP reactivity. Probability of substance use increased over time, but this was amplified for adolescents with greater deviant peer affiliation in conjunction with blunted PEP reactivity. The same pattern of results was also found for prediction of binge drinking and sexual activity involving substance use. Findings are discussed in the context of biosocial models of adolescent substance use and health risk behaviors.

我们评估了不正常的同伴关系与物质使用的开始之间的关联是否取决于性别和交感神经系统 (SNS) 反应性，如通过射血前期 (PEP) 测量的。社区抽样青少年 ( N = 251; M= 15.78 岁；53% 女性；66% 白人，34% 黑人）参加了三波。PEP 反应性是在镜像星-示踪剂压力任务期间收集的。酒精、大麻、烟草或任何物质的使用，以及酗酒和涉及物质使用的性活动都是通过与不正常的同龄人的联系以及与性和 PEP 反应性的两向和三向互动来预测的结果。物质使用的可能性随着时间的推移而增加，但对于具有更大异常同伴关系以及迟钝的 PEP 反应性的青少年来说，这种情况会被放大。同样的结果模式也被发现用于预测酗酒和涉及物质使用的性活动。调查结果在青少年物质使用和健康风险行为的生物社会模型的背景下进行了讨论。