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Simultaneous Determination of Iridoid Glycosides, Phenylpropanoid Glycosides, Organic Acids, Nucleosides and Amino Acids in Scrophulariae Radix Processed by Different Processing Methods by HPLC-QTRAP-MS/MS
Journal of Chromatographic Science ( IF 1.3 ) Pub Date : 2021-06-02 , DOI: 10.1093/chromsci/bmab056
Shengnan Wang 1 , Qin Wang 1 , Xiaoqin Yin 1 , Bohua Chen 1 , Xunhong Liu 2
Affiliation  

Scrophulariae Radix is one of the widely used traditional Chinese medicines. In this study, a high-performance liquid chromatography coupled with triple quadrupole-linear ion trap mass spectrometry method was established for the simultaneous determination of multiple bioactive constituents including four iridoid glycosides, two phenylpropanoid glycosides, six organic acids, 11 nucleosides and 16 amino acids in Scrophulariae Radix. The validated method was used to analyze nine Scrophulariae Radix samples processed by different processing methods. In addition, Grey relational analysis and DTOPSIS were used to evaluate the samples according to the content of 39 ayalytes. The results showed that the quality of Scrophulariae Radix processed by cutting into slices, sun drying and “sweating” methods were better. All the results proved that the developed method was available and could be used to evaluate the quality of Scrophulariae Radix.

中文翻译:

HPLC-QTRAP-MS/MS同时测定不同处理方法处理的玄参中环烯醚萜苷、苯丙苷、有机酸、核苷和氨基酸

玄参是应用广泛的中药材之一。本研究建立了高效液相色谱与三重四极杆-线性离子阱质谱联用的方法,用于同时测定四种环烯醚萜苷、两种苯丙苷、六种有机酸、11种核苷和16种氨基酸等多种生物活性成分。在玄参。采用经过验证的方法分析了九个不同加工方法加工的玄参样品。此外,采用灰色关联分析法和DTOPSIS法根据39种aylytes的含量对样品进行评价。结果表明,玄参切片、晒干和“汗蒸”等方法加工的玄参品质较好。
更新日期:2021-06-02
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