Abstract

The obesity pandemic increasingly causes morbidity and mortality from type 2 diabetes, cardiovascular diseases and many other chronic diseases. Fat cell size (FCS) predicts numerous obesity-related complications such as lipid dysmetabolism, ectopic fat accumulation, insulin resistance, and cardiovascular disorders. Nevertheless, the scarcity of systematic literature reviews on this subject is compounded by the use of different methods by which FCS measurements are determined and reported. In this paper, we provide a systematic review of the current literature on the relationship between adipocyte hypertrophy and obesity-related glucose and lipid dysmetabolism, ectopic fat accumulation, and cardiovascular disorders. We also review the numerous mechanistic origins of adipocyte hypertrophy and its relationship with metabolic dysregulation, including changes in adipogenesis, cell senescence, collagen deposition, systemic inflammation, adipokine secretion, and energy balance. To quantify the effect of different FCS measurement methods, we performed statistical analyses across published data while controlling for body mass index, age, and sex.

中文翻译：

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脂肪细胞大小：测量方法、病理生理学起源以及与代谢异常的关系

摘要

肥胖大流行越来越多地导致 2 型糖尿病、心血管疾病和许多其他慢性疾病的发病率和死亡率。脂肪细胞大小 (FCS) 可预测许多与肥胖相关的并发症，例如脂质代谢异常、异位脂肪堆积、胰岛素抵抗和心血管疾病。然而，由于使用了不同的方法来确定和报告 FCS 测量值，因此缺乏关于该主题的系统文献综述。在本文中，我们对当前关于脂肪细胞肥大与肥胖相关的葡萄糖和脂质代谢异常、异位脂肪积累和心血管疾病之间关系的文献进行了系统回顾。我们还回顾了脂肪细胞肥大的众多机制起源及其与代谢失调的关系，包括脂肪生成、细胞衰老、胶原沉积、全身炎症、脂肪因子分泌和能量平衡的变化。为了量化不同 FCS 测量方法的影响，我们在控制体重指数、年龄和性别的同时对已发布的数据进行了统计分析。