Waterborne polyurethane–acrylate (WPUA) as a surface protective coating has been widely used in industrial, architectural, and textile applications. To extend the application of WPUA in the biological field, a novel ultraviolet-fluorinated waterborne polyurethane–acrylate (UV-WFPUA) film, which contains 2, 4-dihydroxybenzophenone (DHBP) as the ultraviolet (UV) absorber and dodecafluoroheptyl methacrylate (DFMA) as the fluorine monomer, was prepared. The paper discussed the effect of UV absorber and fluorine monomer on the UV adsorption performance, thermo-stability, and physical and mechanical properties of the UV-WFPUA film. Furthermore, it explored the independent and cooperative effects of UV absorber and fluorine monomer in affecting the antiprotein fouling property on a quantitative level. Results show that the antiprotein fouling performance of UV-WFPUA film significantly weakened after adding 0.4 wt.% DHPB since the average protein concentration increased from 0.14 to 0.37 mg/mL. In contrast, after adding 9 wt.% DFMA, the average protein concentration dropped from 0.37 to 0.13 mg/mL, indicating the antiprotein fouling properties improved. Therefore, the addition of fluorine monomer will contribute to antiprotein fouling and eliminate the adhesion of UV absorber with proteins. The excellent antiprotein fouling, thermal, and optical properties endow the waterborne polyurethane–acrylate films with promising applications in corneal contact lenses or intraocular lenses.

水性聚氨酯丙烯酸酯 (WPUA) 作为表面保护涂层已广泛用于工业、建筑和纺织应用。为了扩展 WPUA 在生物领域的应用，一种新型的紫外线氟化水性聚氨酯丙烯酸酯 (UV-WFPUA) 薄膜，其中含有 2, 4-二羟基二苯甲酮 (DHBP) 作为紫外线 (UV) 吸收剂和甲基丙烯酸十二氟庚酯 (DFMA)制备氟单体。文章讨论了紫外线吸收剂和氟单体对UV-WFPUA薄膜的紫外线吸收性能、热稳定性和物理机械性能的影响。此外，它还在定量水平上探讨了紫外线吸收剂和氟单体在影响抗蛋白质污染性能方面的独立和协同作用。结果表明，加入0.4 wt.% DHPB后，UV-WFPUA薄膜的抗蛋白质污染性能显着减弱，因为平均蛋白质浓度从0.14增加到0.37 mg/mL。相比之下，添加 9 wt.% DFMA 后，平均蛋白质浓度从 0.37 降至 0.13 mg/mL，表明抗蛋白质污染性能得到改善。因此，添加氟单体将有助于抗蛋白质污染并消除紫外线吸收剂与蛋白质的粘附。优异的抗蛋白质污染、热和光学性能使水性聚氨酯丙烯酸酯薄膜在角膜隐形眼镜或人工晶状体中具有广阔的应用前景。添加 9 wt.% DFMA 后，平均蛋白质浓度从 0.37 降至 0.13 mg/mL，表明抗蛋白质污染性能得到改善。因此，添加氟单体将有助于抗蛋白质污染并消除紫外线吸收剂与蛋白质的粘附。优异的抗蛋白质污染、热和光学性能使水性聚氨酯丙烯酸酯薄膜在角膜隐形眼镜或人工晶状体中具有广阔的应用前景。添加 9 wt.% DFMA 后，平均蛋白质浓度从 0.37 降至 0.13 mg/mL，表明抗蛋白质污染性能得到改善。因此，添加氟单体将有助于抗蛋白质污染并消除紫外线吸收剂与蛋白质的粘附。优异的抗蛋白质污染、热和光学性能使水性聚氨酯丙烯酸酯薄膜在角膜隐形眼镜或人工晶状体中具有广阔的应用前景。