Animal and clinical studies have revealed that (–)-epigallocatechin-3-O-gallate (EGCG), one of the major bioactive polyphenols in green tea, showed several pharmacological effects including anti-obesity effect and anti-inflammatory effect. We previously reported that the second messenger cyclic guanosine monophosphate (cGMP) mediates its anti-inflammatory and anti-cancer properties. Here we demonstrated that glucosyl-hesperidin, enhances the cGMP-inducing effects of green tea extract in vivo. Moreover, glucosyl-hesperidin intake potentiated the green tea-elicited upregulation of the anti-inflammatory factor, toll-interacting protein.

中文翻译：

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葡萄糖基橙皮苷增强绿茶多酚 EGCG 的环磷酸鸟苷诱导作用

动物和临床研究表明，(-)-epigallocatechin-3- O - gallate (EGCG) 是绿茶中主要的生物活性多酚之一，具有多种药理作用，包括抗肥胖作用和抗炎作用。我们之前曾报道第二信使环磷酸鸟苷 (cGMP) 介导其抗炎和抗癌特性。在这里，我们证明了葡萄糖基橙皮苷在体内增强了绿茶提取物的 cGMP 诱导作用。此外，葡萄糖基橙皮苷的摄入增强了绿茶引起的抗炎因子、收费相互作用蛋白的上调。