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TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis [Plant Biology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.412 ) Pub Date : 2021-06-15 , DOI: 10.1073/pnas.2102544118
Jie Yang, Hang He, Yuming He, Qiaozhen Zheng, Qingzhong Li, Xin Feng, Pengcheng Wang, Guocheng Qin, Yangtao Gu, Ping Wu, Chao Peng, Shilei Sun, Yi Zhang, Mingzhang Wen, Rong Chen, Yang Zhao, Tongda Xu

Differential concentrations of phytohormone trigger distinct outputs, which provides a mechanism for the plasticity of plant development and an adaptation strategy among plants to changing environments. However, the underlying mechanisms of the differential responses remain unclear. Here we report that a high concentration of auxin, distinct from the effect of low auxin concentration, enhances abscisic acid (ABA) responses in Arabidopsis thaliana, which partially relies on TRANS-MEMBERANE KINASE 1 (TMK1), a key regulator in auxin signaling. We show that high auxin and TMK1 play essential and positive roles in ABA signaling through regulating ABA INSENSITIVE 1 and 2 (ABI1/2), two negative regulators of the ABA pathway. TMK1 inhibits the phosphatase activity of ABI2 by direct phosphorylation of threonine 321 (T321), a conserved phosphorylation site in ABI2 proteins, whose phosphorylation status is important for both auxin and ABA responses. This TMK1-dependent auxin signaling in the regulation of ABA responses provides a possible mechanism underlying the high auxin responses in plants and an alternative mechanism involved in the coordination between auxin and ABA signaling.



中文翻译:

基于 TMK1 的生长素信号通过磷酸化拟南芥中的 ABI1/2 调节脱落酸反应 [植物生物学]

不同浓度的植物激素会触发不同的输出,这为植物发育的可塑性和植物对不断变化的环境的适应策略提供了一种机制。然而,差异反应的潜在机制仍不清楚。在这里,我们报告了高浓度的生长素,与低生长素浓度的影响不同,增强了拟南芥中的脱落酸 (ABA) 反应,部分依赖于 TRANS-MEMBERANE KINASE 1 (TMK1),这是生长素信号传导的关键调节因子。我们表明高生长素和 TMK1 通过调节 ABA INSENSITIVE 1 和 2 (ABI1/2)(ABA 通路的两个负调节因子)在 ABA 信号传导中发挥重要和积极的作用。TMK1 通过直接磷酸化苏氨酸 321 (T321) 来抑制 ABI2 的磷酸酶活性,苏氨酸 321 (T321) 是 ABI2 蛋白中一个保守的磷酸化位点,其磷酸化状态对生长素和 ABA 反应都很重要。这种在 ABA 反应调节中的 TMK1 依赖性生长素信号提供了植物中高生长素反应的可能机制,以及涉及生长素和 ABA 信号之间协调的替代机制。

更新日期:2021-06-08
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