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Hesperetin rescues emotional memory and synaptic plasticity deficit in aged rats.
Behavioral Neuroscience ( IF 1.9 ) Pub Date : 2021-06-07 , DOI: 10.1037/bne0000475
Yi Luo 1 , Hua Fan 1 , Xianpei Tan 1 , Zhilian Li 1
Affiliation  

Emotional memory deficit is often accompanied by Alzheimer's disease and normal aging. It is important to do what is possible to alleviate or rescue emotional memory deficit in aging to improve the quality of older adults. Hesperetin is a flavonoid and an aglycone of hesperidin, it easily passes through the blood-brain barrier into the brain and exerts neuroprotective effects. However, little is known about its neuroprotective effect on emotional memory in aging. To address this issue, we examined the role of hesperetin in the regulation of hippocampal long-term potentiation (LTP), surface expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) including glutamate receptor 1 subunit-containing AMPAR (GluA1) and glutamate receptor 1 subunit-containing AMPAR (GluA2), malondialdehyde (MDA) concentration, reduced glutathione (GSH) concentration, and associative fear memory in aged rats. We found that aged rats exhibited impaired emotional memory and LTP. Furthermore, we also found oral administration of hesperetin ameliorated the impairment of emotional memory and LTP. Finally, we demonstrated hesperetin rescued impaired LTP possibly via enhancing AMPAR trafficking and oxidant-antioxidant balance in aged rats. These results imply a pivotal role for hesperetin in synaptic plasticity and associative fear memory in aged rats and suggest that hesperetin is a potential candidate for treating emotional memory deficit in aging. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译:

橙皮素可挽救老年大鼠的情绪记忆和突触可塑性缺陷。

情绪记忆缺陷往往伴随着阿尔茨海默病和正常衰老。重要的是尽一切可能减轻或挽救衰老过程中的情绪记忆缺陷,以提高老年人的素质。橙皮素是一种黄酮类化合物和橙皮苷的苷元,它很容易通过血脑屏障进入大脑并发挥神经保护作用。然而,关于其对衰老过程中情绪记忆的神经保护作用知之甚少。为了解决这个问题,我们研究了橙皮素在调节海马长时程增强 (LTP)、包括谷氨酸受体在内的 α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体 (AMPAR) 的表面表达中的作用含 1 个亚基的 AMPAR (GluA1) 和含谷氨酸受体 1 个亚基的 AMPAR (GluA2),丙二醛 (MDA) 浓度,降低老年大鼠的谷胱甘肽 (GSH) 浓度和相关恐惧记忆。我们发现老年大鼠表现出情绪记忆和 LTP 受损。此外,我们还发现口服橙皮素可改善情绪记忆和 LTP 的损害。最后,我们证明橙皮素可能通过增强老年大鼠的 AMPAR 运输和氧化-抗氧化平衡来挽救受损的 LTP。这些结果暗示橙皮素在老年大鼠的突触可塑性和联想恐惧记忆中起关键作用,并表明橙皮素是治疗衰老中情绪记忆缺陷的潜在候选者。(PsycInfo 数据库记录 (c) 2021 APA,保留所有权利)。我们还发现口服橙皮素可改善情绪记忆和 LTP 的损害。最后,我们证明橙皮素可能通过增强老年大鼠的 AMPAR 运输和氧化-抗氧化平衡来挽救受损的 LTP。这些结果暗示橙皮素在老年大鼠的突触可塑性和联想恐惧记忆中起关键作用,并表明橙皮素是治疗衰老中情绪记忆缺陷的潜在候选者。(PsycInfo 数据库记录 (c) 2021 APA,保留所有权利)。我们还发现口服橙皮素可改善情绪记忆和 LTP 的损害。最后,我们证明橙皮素可能通过增强老年大鼠的 AMPAR 运输和氧化-抗氧化平衡来挽救受损的 LTP。这些结果暗示橙皮素在老年大鼠的突触可塑性和联想恐惧记忆中起关键作用,并表明橙皮素是治疗衰老中情绪记忆缺陷的潜在候选者。(PsycInfo 数据库记录 (c) 2021 APA,保留所有权利)。这些结果暗示橙皮素在老年大鼠的突触可塑性和联想恐惧记忆中起关键作用,并表明橙皮素是治疗衰老中情绪记忆缺陷的潜在候选者。(PsycInfo 数据库记录 (c) 2021 APA,保留所有权利)。这些结果暗示橙皮素在老年大鼠的突触可塑性和联想恐惧记忆中起关键作用,并表明橙皮素是治疗衰老中情绪记忆缺陷的潜在候选者。(PsycInfo 数据库记录 (c) 2021 APA,保留所有权利)。
更新日期:2021-06-09
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