Genome editing with CRISPR–Cas9 is beginning to be used clinically; promising results to date inspire hope for broad medical impact and mindfulness about safety. A new study shows that when Cas9 cuts its target, a fraction of the time, the target chromosome experiences a breakage process known as chromothripsis, thus prompting efforts to understand the potential negative consequences of this phenomenon and ways to mitigate them.

中文翻译：

---

CRISPR–Cas9 可导致染色体碎裂

使用 CRISPR–Cas9 进行基因组编辑开始在临床上使用；迄今为止有希望的结果激发了对广泛的医学影响和对安全性的关注的希望。一项新的研究表明，当 Cas9 切割其目标时，目标染色体在少数情况下会经历称为染色体碎裂的断裂过程，从而促使人们努力了解这种现象的潜在负面后果以及减轻它们的方法。