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Research for Expression and Prognostic Value of GABRD in Colon Cancer and Coexpressed Gene Network Construction Based on Data Mining
Computational and Mathematical Methods in Medicine ( IF 2.809 ) Pub Date : 2021-06-07 , DOI: 10.1155/2021/5544182
Tao Liu 1 , Yuejun Fang 1
Affiliation  

Colon cancer is one of the top five cancers with the highest incidence rate in the world. In order to better understand the pathogenesis and progression of colon cancer, it is still necessary to investigate the abnormally expressed genes in cancer tissue. In this study, the Oncomine database was used for expression analysis, and it was found that the expression level of gamma-aminobutyric acid type A receptor subunit delta (GABRD) gene was upregulated in colon cancer tissue compared with that in normal tissue. UALCAN was used to analyze the expression of GABRD in different groups of age, gender, cancer stage, N stage, and histological subtype. Then, it was also found that the expression of GABRD in each subgroup of colon cancer tissue was all high compared with that in normal tissue. LinkedOmics was used to screen out the differentially expressed genes related to GABRD expression in colon cancer. GO annotation and KEGG pathway enrichment analyses found that the correlated genes may be related to breast cancer, human papillomavirus infection, Notch signaling pathway, and other pathways. Thereafter, GSEA was performed to obtain GABRD-related kinases, miRNAs, and transcription factors, and gene interaction networks were constructed. It was found that GABRD may be involved in cell cycle regulation. Finally, websites like GEPIA were used to detect the predictive ability of GABRD on the prognosis of patients with colon cancer. Kaplan-Meier analysis suggested that the upregulation of GABRD expression was related to the poor prognosis of patients with colon cancer. Overall, in this study, the potential role and prognostic ability of GABRD in colon cancer were explored through data mining, which can be a clue for further research on GABRD.

中文翻译:

基于数据挖掘的GABRD在结肠癌中的表达及预后价值研究及共表达基因网络构建

结肠癌是世界上发病率最高的五种癌症之一。为了更好地了解结肠癌的发病机制和进展,仍需对癌组织中异常表达的基因进行研究。本研究利用Oncomine数据库进行表达分析,发现与正常组织相比,γ-氨基丁酸A型受体亚基δ(GABRD)基因在结肠癌组织中的表达水平上调。使用UALCAN分析GABRD在不同年龄、性别、癌症分期、N分期和组织学亚型中的表达情况。然后还发现GABRD在各亚组结肠癌组织中的表达均高于正常组织。LinkedOmics用于筛选结肠癌中与GABRD表达相关的差异表达基因。GO注释和KEGG通路富集分析发现相关基因可能与乳腺癌、人乳头瘤病毒感染、Notch信号通路等通路有关。此后,进行GSEA 获得GABRD 相关激酶、miRNA 和转录因子,并构建基因相互作用网络。发现GABRD可能参与细胞周期调控。最后,通过GEPIA等网站检测GABRD对结肠癌患者预后的预测能力。Kaplan-Meier分析提示GABRD表达上调与结肠癌患者预后不良有关。总的来说,在本研究中,
更新日期:2021-06-07
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