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Eosinophils in skin diseases
Seminars in Immunopathology ( IF 9 ) Pub Date : 2021-06-07 , DOI: 10.1007/s00281-021-00868-7
Susanne Radonjic-Hoesli 1 , Marie-Charlotte Brüggen 2, 3, 4 , Laurence Feldmeyer 1 , Hans-Uwe Simon 5, 6, 7 , Dagmar Simon 1
Affiliation  

Eosinophil infiltration is a common finding in a broad spectrum of skin diseases, despite the fact that the skin is devoid of eosinophils under physiologic conditions. Although cutaneous eosinophilia is reactive, cytokine-mediated in most cases, diseases with an intrinsic mutation-mediated clonal expansion of eosinophils can also manifest on the skin. As eosinophils are involved in host defense, regulate immune responses, generate pruritus, induce remodeling and fibrosis, and can cause tissue damage, they have the capacity to actively contribute to the pathogenesis of diseases. Recent research provided deeper insights in the mechanisms, e.g., bacterial and viral clearance, blister formation, recruitment of cytotoxic T cells, and generation of pruritus, by which eosinophils might come into action. This review aims at providing an overview on the clinical presentations of eosinophil-associated dermatoses and the current understanding of their pathogenic role in these diseases. Further, we discuss the effects of therapies targeting eosinophils.



中文翻译:

皮肤病中的嗜酸性粒细胞

尽管在生理条件下皮肤缺乏嗜酸性粒细胞,但嗜酸性粒细胞浸润是多种皮肤病的常见现象。尽管皮肤嗜酸性粒细胞增多是反应性的,在大多数情况下是细胞因子介导的,但具有内在突变介导的嗜酸性粒细胞克隆扩张的疾病也可以在皮肤上表现出来。由于嗜酸性粒细胞参与宿主防御、调节免疫反应、产生瘙痒、诱导重塑和纤维化,并可引起组织损伤,因此它们有能力积极促进疾病的发病机制。最近的研究对嗜酸性粒细胞可能发挥作用的细菌和病毒清除、水疱形成、细胞毒性T细胞的募集以及瘙痒的产生等机制提供了更深入的见解。本综述旨在概述嗜酸性粒细胞相关皮肤病的临床表现以及目前对其在这些疾病中致病作用的认识。此外,我们讨论了针对嗜酸性粒细胞的治疗的效果。

更新日期:2021-06-07
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