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Spread of a SARS-CoV-2 variant through Europe in the summer of 2020
Nature ( IF 64.8 ) Pub Date : 2021-06-07 , DOI: 10.1038/s41586-021-03677-y
Emma B Hodcroft 1, 2, 3 , Moira Zuber 1 , Sarah Nadeau 2, 4 , Timothy G Vaughan 2, 4 , Katharine H D Crawford 5, 6, 7 , Christian L Althaus 3 , Martina L Reichmuth 3 , John E Bowen 8 , Alexandra C Walls 8 , Davide Corti 9 , Jesse D Bloom 5, 6, 10 , David Veesler 8 , David Mateo 11 , Alberto Hernando 11 , Iñaki Comas 12, 13 , Fernando González-Candelas 13, 14 , , Tanja Stadler 2, 4 , Richard A Neher 1, 2
Affiliation  

Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3,4,5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes.



中文翻译:

2020 年夏天 SARS-CoV-2 变体在欧洲传播

在 2019 年底出现后,SARS-CoV-2 1,2的传播已通过对病毒基因组序列的系统发育分析进行了前所未有的详细跟踪3,4,5. 尽管该病毒在边境关闭之前于 2020 年初在全球传播,但此后洲际旅行已大大减少。然而,欧洲境内的旅行于 2020 年夏季恢复。在这里,我们报告了一种 SARS-CoV-2 变体 20E (EU1),该变体于 2020 年初夏在西班牙被发现并随后传播到整个欧洲。我们没有发现任何证据表明这种变体增加了传播性,而是证明了西班牙发病率的上升、旅行的恢复以及缺乏有效的筛查和遏制可能解释了该变体的成功。尽管有旅行限制,我们估计 20E (EU1) 已被夏季旅行者数百次引入欧洲国家,这可能会破坏当地为减少 SARS-CoV-2 感染所做的努力。我们的研究结果表明,即使在有利的流行病学环境中没有显着的传播优势,变异如何迅速成为主导。基因组监测对于了解旅行如何影响 SARS-CoV-2 的传播至关重要,从而在旅行恢复时为未来的遏制策略提供信息。

更新日期:2021-06-07
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