The treatment of ameloblastoma, an odontogenic epithelial tumour destroying jawbone, mainly depends on radical destructive resections. Other therapeutic options are limited by the characteristics of ameloblastoma, such as high recurrence rates and resistance to radiation and chemotherapy, which implies possible existence of cancer stem cells (CSCs) in ameloblastoma. Here, we identified a putative CSC population in immortalized and primary human ameloblastoma cells and examined possible therapeutic reagents to reduce the CSC population.

中文翻译：

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Wnt信号的激活减少了成釉细胞瘤中癌症干细胞的数量

成釉细胞瘤是一种破坏颌骨的牙源性上皮肿瘤，其治疗主要依赖于根治性破坏性切除。其他治疗选择受到成釉细胞瘤特征的限制，例如高复发率和对放疗和化疗的抵抗力，这意味着成釉细胞瘤中可能存在癌症干细胞 (CSC)。在这里，我们在永生化和原代人成釉细胞瘤细胞中确定了一个假定的 CSC 群体，并检查了可能的治疗试剂以减少 CSC 群体。