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The fibroblast: An emerging key player in thymic T cell selection
Immunological Reviews ( IF 8.7 ) Pub Date : 2021-06-06 , DOI: 10.1111/imr.12985
Takeshi Nitta 1 , Ayami Ota 1 , Takahiro Iguchi 1 , Ryunosuke Muro 1 , Hiroshi Takayanagi 1
Affiliation  

Fibroblasts have recently attracted attention as a key stromal component that controls the immune responses in lymphoid tissues. The thymus has a unique microenvironment comprised of a variety of stromal cells, including fibroblasts and thymic epithelial cells (TECs), the latter of which is known to be important for T cell development because of their ability to express self-antigens. Thymic fibroblasts contribute to thymus organogenesis during embryogenesis and form the capsule and medullary reticular network in the adult thymus. However, the immunological significance of thymic fibroblasts has thus far only been poorly elucidated. In this review, we will summarize the current views on the development and functions of thymic fibroblasts as revealed by new technologies such as multicolor flow cytometry and single cell–based transcriptome profiling. Furthermore, the recently discovered role of medullary fibroblasts in the establishment of T cell tolerance by producing a unique set of self-antigens will be highlighted.

中文翻译:

成纤维细胞:胸腺 T 细胞选择的新兴关键参与者

成纤维细胞最近作为控制淋巴组织免疫反应的关键基质成分引起了人们的注意。胸腺具有独特的微环境,由各种基质细胞组成,包括成纤维细胞和胸腺上皮细胞 (TEC),后者因表达自身抗原的能力而对 T 细胞发育很重要。胸腺成纤维细胞在胚胎发生过程中促进胸腺器官发生,并在成年胸腺中形成荚膜和髓质网状网络。然而,胸腺成纤维细胞的免疫学意义迄今尚未阐明。在这篇综述中,我们将总结目前对多色流式细胞术和基于单细胞的转录组分析等新技术所揭示的胸腺成纤维细胞发育和功能的看法。
更新日期:2021-07-19
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